2dsb: Difference between revisions

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[[Image:2dsb.png|left|200px]]


{{STRUCTURE_2dsb| PDB=2dsb | SCENE= }}
==Crystal structure of human ADP-ribose pyrophosphatase NUDT5==
<StructureSection load='2dsb' size='340' side='right'caption='[[2dsb]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2dsb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DSB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsb OCA], [https://pdbe.org/2dsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dsb RCSB], [https://www.ebi.ac.uk/pdbsum/2dsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NUDT5_HUMAN NUDT5_HUMAN] Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity.<ref>PMID:17052728</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/2dsb_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dsb ConSurf].
<div style="clear:both"></div>


===Crystal structure of human ADP-ribose pyrophosphatase NUDT5===
==See Also==
 
*[[ADP-ribose pyrophosphatase 3D structures|ADP-ribose pyrophosphatase 3D structures]]
{{ABSTRACT_PUBMED_17052728}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[2dsb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSB OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:017052728</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ding, J.]]
[[Category: Large Structures]]
[[Category: Zha, M.]]
[[Category: Ding J]]
[[Category: Zhong, C.]]
[[Category: Zha M]]
[[Category: Adp-ribose pyrophosphatase]]
[[Category: Zhong C]]
[[Category: Adpr]]
[[Category: Hydrolase]]
[[Category: Nudix domain]]
[[Category: Nudt5]]

Latest revision as of 16:48, 13 March 2024

Crystal structure of human ADP-ribose pyrophosphatase NUDT5Crystal structure of human ADP-ribose pyrophosphatase NUDT5

Structural highlights

2dsb is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NUDT5_HUMAN Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Zha M, Zhong C, Peng Y, Hu H, Ding J. Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity. J Mol Biol. 2006 Dec 15;364(5):1021-33. Epub 2006 Oct 3. PMID:17052728 doi:10.1016/j.jmb.2006.09.078

2dsb, resolution 2.50Å

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OCA
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