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==The structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probe== | ==The structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probe== | ||
<StructureSection load='2doo' size='340' side='right' caption='[[2doo]], [[Resolution|resolution]] 2.43Å' scene=''> | <StructureSection load='2doo' size='340' side='right'caption='[[2doo]], [[Resolution|resolution]] 2.43Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2doo]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2doo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DOO FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C4H:N-[4-({[5-(DIMETHYLAMINO)-1-NAPHTHYL]SULFONYL}AMINO)BUTYL]-3-SULFANYLPROPANAMIDE'>C4H</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2doo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doo OCA], [https://pdbe.org/2doo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2doo RCSB], [https://www.ebi.ac.uk/pdbsum/2doo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2doo ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Beta-lactamase|Beta-lactamase]] | *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arakawa | [[Category: Serratia marcescens]] | ||
[[Category: Jin | [[Category: Arakawa Y]] | ||
[[Category: Kurosaki | [[Category: Jin W]] | ||
[[Category: Yamagata | [[Category: Kurosaki H]] | ||
[[Category: Yamaguchi | [[Category: Yamagata Y]] | ||
[[Category: Yasuzawa | [[Category: Yamaguchi Y]] | ||
[[Category: Yasuzawa H]] | |||
Latest revision as of 16:47, 13 March 2024
The structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probeThe structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probe
Structural highlights
FunctionBLAB_SERMA Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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