2doo: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(12 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2doo.jpg|left|200px]]


{{Structure
==The structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probe==
|PDB= 2doo |SIZE=350|CAPTION= <scene name='initialview01'>2doo</scene>, resolution 2.43&Aring;
<StructureSection load='2doo' size='340' side='right'caption='[[2doo]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=C4H:N-[4-({[5-(DIMETHYLAMINO)-1-NAPHTHYL]SULFONYL}AMINO)BUTYL]-3-SULFANYLPROPANAMIDE'>C4H</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
<table><tr><td colspan='2'>[[2doo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DOO FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
|GENE= BLAIMP-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=615 Serratia marcescens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C4H:N-[4-({[5-(DIMETHYLAMINO)-1-NAPHTHYL]SULFONYL}AMINO)BUTYL]-3-SULFANYLPROPANAMIDE'>C4H</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2doo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doo OCA], [https://pdbe.org/2doo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2doo RCSB], [https://www.ebi.ac.uk/pdbsum/2doo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2doo ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doo OCA], [http://www.ebi.ac.uk/pdbsum/2doo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2doo RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/2doo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2doo ConSurf].
<div style="clear:both"></div>


'''The structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probe'''
==See Also==
 
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2DOO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOO OCA].
[[Category: Large Structures]]
 
==Reference==
Probing, inhibition, and crystallographic characterization of metallo-beta-lactamase (IMP-1) with fluorescent agents containing dansyl and thiol groups., Kurosaki H, Yamaguchi Y, Yasuzawa H, Jin W, Yamagata Y, Arakawa Y, ChemMedChem. 2006 Sep;1(9):969-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16937423 16937423]
[[Category: Beta-lactamase]]
[[Category: Serratia marcescens]]
[[Category: Serratia marcescens]]
[[Category: Single protein]]
[[Category: Arakawa Y]]
[[Category: Arakawa, Y.]]
[[Category: Jin W]]
[[Category: Jin, W.]]
[[Category: Kurosaki H]]
[[Category: Kurosaki, H.]]
[[Category: Yamagata Y]]
[[Category: Yamagata, Y.]]
[[Category: Yamaguchi Y]]
[[Category: Yamaguchi, Y.]]
[[Category: Yasuzawa H]]
[[Category: Yasuzawa, H.]]
[[Category: metallo-beta-lactamase]]
[[Category: protein-inhibitor complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:37:34 2008''

Latest revision as of 16:47, 13 March 2024

The structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probeThe structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probe

Structural highlights

2doo is a 2 chain structure with sequence from Serratia marcescens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.43Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BLAB_SERMA Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2doo, resolution 2.43Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2doo&oldid=4088710"