2doo: Difference between revisions

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-[[Image:2doo.jpg|left|200px]]
- {{Structure
+==The structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probe==
-|PDB= 2doo |SIZE=350|CAPTION= <scene name='initialview01'>2doo</scene>, resolution 2.43&Aring;
+<StructureSection load='2doo' size='340' side='right'caption='[[2doo]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=C4H:N-[4-({[5-(DIMETHYLAMINO)-1-NAPHTHYL]SULFONYL}AMINO)BUTYL]-3-SULFANYLPROPANAMIDE'>C4H</scene>
+<table><tr><td colspan='2'>[[2doo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DOO FirstGlance]. <br>
-|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
-|GENE= BLAIMP-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=615 Serratia marcescens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C4H:N-[4-({[5-(DIMETHYLAMINO)-1-NAPHTHYL]SULFONYL}AMINO)BUTYL]-3-SULFANYLPROPANAMIDE'>C4H</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2doo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doo OCA], [https://pdbe.org/2doo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2doo RCSB], [https://www.ebi.ac.uk/pdbsum/2doo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2doo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/2doo_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2doo ConSurf].
+<div style="clear:both"></div>
-'''The structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probe'''
+==See Also==
+*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-DOO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOO OCA].
+[[Category: Large Structures]]
-==Reference==
-Probing, inhibition, and crystallographic characterization of metallo-beta-lactamase (IMP-1) with fluorescent agents containing dansyl and thiol groups., Kurosaki H, Yamaguchi Y, Yasuzawa H, Jin W, Yamagata Y, Arakawa Y, ChemMedChem. 2006 Sep;1(9):969-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16937423 16937423]
-[[Category: Beta-lactamase]]
 [[Category: Serratia marcescens]]
-[[Category: Single protein]]
+[[Category: Arakawa Y]]
-[[Category: Arakawa, Y.]]
+[[Category: Jin W]]
-[[Category: Jin, W.]]
+[[Category: Kurosaki H]]
-[[Category: Kurosaki, H.]]
+[[Category: Yamagata Y]]
-[[Category: Yamagata, Y.]]
+[[Category: Yamaguchi Y]]
-[[Category: Yamaguchi, Y.]]
+[[Category: Yasuzawa H]]
-[[Category: Yasuzawa, H.]]
-[[Category: C4H]]
-[[Category: ZN]]
-[[Category: metallo-beta-lactamase]]
-[[Category: protein-inhibitor complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:29:49 2008''