2dkd: Difference between revisions

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[[Image:2dkd.png|left|200px]]


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==Crystal structure of N-acetylglucosamine-phosphate mutase, a member of the alpha-D-phosphohexomutase superfamily, in the product complex==
The line below this paragraph, containing "STRUCTURE_2dkd", creates the "Structure Box" on the page.
<StructureSection load='2dkd' size='340' side='right'caption='[[2dkd]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2dkd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DKD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NG1:N-ACETYL-ALPHA-D-GALACTOSAMINE+1-PHOSPHATE'>NG1</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_2dkd|  PDB=2dkd  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dkd OCA], [https://pdbe.org/2dkd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dkd RCSB], [https://www.ebi.ac.uk/pdbsum/2dkd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dkd ProSAT]</span></td></tr>
 
</table>
===Crystal structure of N-acetylglucosamine-phosphate mutase, a member of the alpha-D-phosphohexomutase superfamily, in the product complex===
== Function ==
 
[https://www.uniprot.org/uniprot/AGM1_CANAX AGM1_CANAX] Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.<ref>PMID:11004509</ref>  
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/2dkd_consurf.spt"</scriptWhenChecked>
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2DKD is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKD OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dkd ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:16651269</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Candida albicans]]
[[Category: Candida albicans]]
[[Category: Phosphoacetylglucosamine mutase]]
[[Category: Large Structures]]
[[Category: Fukami, T A.]]
[[Category: Fukami TA]]
[[Category: Kita, A.]]
[[Category: Kita A]]
[[Category: Maruyama, D.]]
[[Category: Maruyama D]]
[[Category: Miki, K.]]
[[Category: Miki K]]
[[Category: Mio, T.]]
[[Category: Mio T]]
[[Category: Nishitani, Y.]]
[[Category: Nishitani Y]]
[[Category: Nonaka, T.]]
[[Category: Nonaka T]]
[[Category: Yamada-Okabe, H.]]
[[Category: Yamada-Okabe H]]
[[Category: Yamada-Okabe, T.]]
[[Category: Yamada-Okabe T]]
[[Category: Mutase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:52:00 2009''

Latest revision as of 16:47, 13 March 2024

Crystal structure of N-acetylglucosamine-phosphate mutase, a member of the alpha-D-phosphohexomutase superfamily, in the product complexCrystal structure of N-acetylglucosamine-phosphate mutase, a member of the alpha-D-phosphohexomutase superfamily, in the product complex

Structural highlights

2dkd is a 2 chain structure with sequence from Candida albicans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AGM1_CANAX Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Mio T, Yamada-Okabe T, Arisawa M, Yamada-Okabe H. Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):369-76. PMID:11004509

2dkd, resolution 2.10Å

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