2d2s: Difference between revisions

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-[[Image:2d2s.jpg|left|200px]]
- {{Structure
+==Crystal Structure of the Exo84p C-terminal Domains==
-|PDB= 2d2s |SIZE=350|CAPTION= <scene name='initialview01'>2d2s</scene>, resolution 2.85&Aring;
+<StructureSection load='2d2s' size='340' side='right'caption='[[2d2s]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[2d2s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D2S FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d2s OCA], [https://pdbe.org/2d2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d2s RCSB], [https://www.ebi.ac.uk/pdbsum/2d2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d2s ProSAT]</span></td></tr>
-|DOMAIN=
+</table>
-|RELATEDENTRY=[[2b1e|2B1E]]
+== Function ==
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d2s OCA], [http://www.ebi.ac.uk/pdbsum/2d2s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2d2s RCSB]</span>
+[https://www.uniprot.org/uniprot/EXO84_YEAST EXO84_YEAST] Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis and to the budding site. Also involved in assembly of the spliceosome.<ref>PMID:10438536</ref> <ref>PMID:11425851</ref> <ref>PMID:15788396</ref>
-}}
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-'''Crystal Structure of the Exo84p C-terminal Domains'''
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/2d2s_consurf.spt"</scriptWhenChecked>
-==Overview==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-The exocyst is a large complex that is required for tethering vesicles at the final stages of the exocytic pathway in all eukaryotes. Here we present the structures of the Exo70p subunit of this complex and of the C-terminal domains of Exo84p, at 2.0-A and 2.85-A resolution, respectively. Exo70p forms a 160-A-long rod with a novel fold composed of contiguous alpha-helical bundles. The Exo84p C terminus also forms a long rod (80 A), which unexpectedly has the same fold as the Exo70p N terminus. Our structural results and our experimental observations concerning the interaction between Exo70p and other exocyst subunits or Rho3p GTPase are consistent with an architecture wherein exocyst subunits are composed of mostly helical modules strung together into long rods.
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==About this Structure==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d2s ConSurf].
-D2S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D2S OCA].
+<div style="clear:both"></div>
+== References ==
-==Reference==
+<references/>
-The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif., Dong G, Hutagalung AH, Fu C, Novick P, Reinisch KM, Nat Struct Mol Biol. 2005 Dec;12(12):1094-100. Epub 2005 Oct 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16249794 16249794]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Single protein]]
+[[Category: Dong G]]
-[[Category: Dong, G.]]
+[[Category: Fu C]]
-[[Category: Fu, C.]]
+[[Category: Hutagalung AH]]
-[[Category: Hutagalung, A H.]]
+[[Category: Novick P]]
-[[Category: Novick, P.]]
+[[Category: Reinisch KM]]
-[[Category: Reinisch, K M.]]
-[[Category: exo84p]]
-[[Category: exocyst]]
-[[Category: tethering complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:29:37 2008''