2cxs: Difference between revisions
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==Crystal structure of mouse AMF / F6P complex== | |||
<StructureSection load='2cxs' size='340' side='right'caption='[[2cxs]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2cxs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CXS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cxs OCA], [https://pdbe.org/2cxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cxs RCSB], [https://www.ebi.ac.uk/pdbsum/2cxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cxs ProSAT]</span></td></tr> | ||
[[2cxs]] is a 2 chain structure | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/G6PI_MOUSE G6PI_MOUSE] Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/2cxs_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cxs ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Phosphoglucose isomerase|Phosphoglucose isomerase]] | *[[Phosphoglucose isomerase 3D structures|Phosphoglucose isomerase 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Funasaka | [[Category: Funasaka T]] | ||
[[Category: Haga | [[Category: Haga A]] | ||
[[Category: Hashimoto | [[Category: Hashimoto K]] | ||
[[Category: Kusakabe | [[Category: Kusakabe Y]] | ||
[[Category: Naba | [[Category: Naba N]] | ||
[[Category: Nagase | [[Category: Nagase H]] | ||
[[Category: Nakamura | [[Category: Nakamura KT]] | ||
[[Category: Raz | [[Category: Raz A]] | ||
[[Category: Shiraiwa | [[Category: Shiraiwa K]] | ||
[[Category: Tanaka | [[Category: Tanaka N]] | ||
Latest revision as of 16:44, 13 March 2024
Crystal structure of mouse AMF / F6P complexCrystal structure of mouse AMF / F6P complex
Structural highlights
FunctionG6PI_MOUSE Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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