2cxo: Difference between revisions

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{{Seed}}
[[Image:2cxo.png|left|200px]]


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==Crystal structure of mouse AMF / E4P complex==
The line below this paragraph, containing "STRUCTURE_2cxo", creates the "Structure Box" on the page.
<StructureSection load='2cxo' size='340' side='right'caption='[[2cxo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2cxo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CXO FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DER:D-4-PHOSPHOERYTHRONIC+ACID'>DER</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_2cxo| PDB=2cxo |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cxo OCA], [https://pdbe.org/2cxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cxo RCSB], [https://www.ebi.ac.uk/pdbsum/2cxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cxo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G6PI_MOUSE G6PI_MOUSE] Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/2cxo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cxo ConSurf].
<div style="clear:both"></div>


===Crystal structure of mouse AMF / E4P complex===
==See Also==
 
*[[Phosphoglucose isomerase 3D structures|Phosphoglucose isomerase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_16375918}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 16375918 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16375918}}
 
==About this Structure==
2CXO is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CXO OCA].
 
==Reference==
<ref group="xtra">PMID:16375918</ref><references group="xtra"/>
[[Category: Glucose-6-phosphate isomerase]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Funasaka, T.]]
[[Category: Funasaka T]]
[[Category: Haga, A.]]
[[Category: Haga A]]
[[Category: Hashimoto, K.]]
[[Category: Hashimoto K]]
[[Category: Kusakabe, Y.]]
[[Category: Kusakabe Y]]
[[Category: Naba, N.]]
[[Category: Naba N]]
[[Category: Nagase, H.]]
[[Category: Nagase H]]
[[Category: Nakamura, K T.]]
[[Category: Nakamura KT]]
[[Category: Raz, A.]]
[[Category: Raz A]]
[[Category: Shiraiwa, K.]]
[[Category: Shiraiwa K]]
[[Category: Tanaka, N.]]
[[Category: Tanaka N]]
[[Category: Isomerase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:31:55 2009''

Latest revision as of 16:44, 13 March 2024

Crystal structure of mouse AMF / E4P complexCrystal structure of mouse AMF / E4P complex

Structural highlights

2cxo is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

G6PI_MOUSE Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2cxo, resolution 1.80Å

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