2cxo: Difference between revisions

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-{{Seed}}
-[[Image:2cxo.png|left|200px]]
-<!--
+==Crystal structure of mouse AMF / E4P complex==
-The line below this paragraph, containing "STRUCTURE_2cxo", creates the "Structure Box" on the page.
+<StructureSection load='2cxo' size='340' side='right'caption='[[2cxo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2cxo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CXO FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DER:D-4-PHOSPHOERYTHRONIC+ACID'>DER</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-{{STRUCTURE_2cxo|  PDB=2cxo  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cxo OCA], [https://pdbe.org/2cxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cxo RCSB], [https://www.ebi.ac.uk/pdbsum/2cxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cxo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/G6PI_MOUSE G6PI_MOUSE] Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/2cxo_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cxo ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of mouse AMF / E4P complex===
+==See Also==
+*[[Phosphoglucose isomerase 3D structures|Phosphoglucose isomerase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_16375918}}, adds the Publication Abstract to the page
+[[Category: Large Structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 16375918 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_16375918}}
-==About this Structure==
-CXO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CXO OCA].
-==Reference==
-Crystal structures of mouse autocrine motility factor in complex with carbohydrate phosphate inhibitors provide insight into structure-activity relationship of the inhibitors., Tanaka N, Haga A, Naba N, Shiraiwa K, Kusakabe Y, Hashimoto K, Funasaka T, Nagase H, Raz A, Nakamura KT, J Mol Biol. 2006 Feb 17;356(2):312-24. Epub 2005 Dec 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16375918 16375918]
-[[Category: Glucose-6-phosphate isomerase]]
 [[Category: Mus musculus]]
-[[Category: Single protein]]
+[[Category: Funasaka T]]
-[[Category: Funasaka, T.]]
+[[Category: Haga A]]
-[[Category: Haga, A.]]
+[[Category: Hashimoto K]]
-[[Category: Hashimoto, K.]]
+[[Category: Kusakabe Y]]
-[[Category: Kusakabe, Y.]]
+[[Category: Naba N]]
-[[Category: Naba, N.]]
+[[Category: Nagase H]]
-[[Category: Nagase, H.]]
+[[Category: Nakamura KT]]
-[[Category: Nakamura, K T.]]
+[[Category: Raz A]]
-[[Category: Raz, A.]]
+[[Category: Shiraiwa K]]
-[[Category: Shiraiwa, K.]]
+[[Category: Tanaka N]]
-[[Category: Tanaka, N.]]
-[[Category: Isomerase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:54:39 2008''