2cxn: Difference between revisions
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==Crystal structure of mouse AMF / phosphate complex== | |||
<StructureSection load='2cxn' size='340' side='right'caption='[[2cxn]], [[Resolution|resolution]] 1.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2cxn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CXN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cxn OCA], [https://pdbe.org/2cxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cxn RCSB], [https://www.ebi.ac.uk/pdbsum/2cxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cxn ProSAT]</span></td></tr> | ||
[[2cxn]] is a 2 chain structure | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/G6PI_MOUSE G6PI_MOUSE] Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/2cxn_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cxn ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Phosphoglucose isomerase 3D structures|Phosphoglucose isomerase 3D structures]] | |||
*[[Phosphoglucose isomerase|Phosphoglucose isomerase]] | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Funasaka | [[Category: Funasaka T]] | ||
[[Category: Haga | [[Category: Haga A]] | ||
[[Category: Hashimoto | [[Category: Hashimoto K]] | ||
[[Category: Kusakabe | [[Category: Kusakabe Y]] | ||
[[Category: Naba | [[Category: Naba N]] | ||
[[Category: Nagase | [[Category: Nagase H]] | ||
[[Category: Nakamura | [[Category: Nakamura KT]] | ||
[[Category: Raz | [[Category: Raz A]] | ||
[[Category: Shiraiwa | [[Category: Shiraiwa K]] | ||
[[Category: Tanaka | [[Category: Tanaka N]] | ||
Latest revision as of 16:44, 13 March 2024
Crystal structure of mouse AMF / phosphate complexCrystal structure of mouse AMF / phosphate complex
Structural highlights
FunctionG6PI_MOUSE Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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