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[[Image:2cw2.gif|left|200px]]


{{Structure
==Crystal structure of Superoxide dismutase from P. Marinus==
|PDB= 2cw2 |SIZE=350|CAPTION= <scene name='initialview01'>2cw2</scene>, resolution 1.86&Aring;
<StructureSection load='2cw2' size='340' side='right'caption='[[2cw2]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>
<table><tr><td colspan='2'>[[2cw2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Perkinsus_marinus Perkinsus marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CW2 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cw2 OCA], [https://pdbe.org/2cw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cw2 RCSB], [https://www.ebi.ac.uk/pdbsum/2cw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cw2 ProSAT]</span></td></tr>
|RELATEDENTRY=[[2cw3|2CW3]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cw2 OCA], [http://www.ebi.ac.uk/pdbsum/2cw2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cw2 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/Q8ISJ0_9ALVE Q8ISJ0_9ALVE] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[RuleBase:RU000414]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/2cw2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cw2 ConSurf].
<div style="clear:both"></div>


'''Crystal structure of Superoxide dismutase from P. Marinus'''
==See Also==
 
*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
Perkinsus marinus, a facultative intracellular parasite of the eastern oyster Crassostrea virginica, is responsible for mass mortalities of oyster populations. P. marinus trophozoites survive and proliferate within oyster hemocytes, invading most tissues and fluids, thus causing a systemic infection that eventually kills the host. The phagocytosis of P. marinus trophozoites lacks a respiratory burst, suggesting that the parasite has mechanisms that actively abrogate the host's oxidative defense responses. One mechanism and the first line of defense against oxidative damage is the dismutation of superoxide radical to molecular oxygen and hydrogen peroxide by superoxide dismutases (SODs). P. marinus possesses two iron-cofactored SODs, PmSOD1 and PmSOD2. Here, the crystallization and X-ray structures of both PmSOD1 and PmSOD2 are presented.
[[Category: Large Structures]]
 
==About this Structure==
2CW2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Perkinsus_marinus Perkinsus marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CW2 OCA].
 
==Reference==
Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus., Asojo OA, Schott EJ, Vasta GR, Silva AM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1072-5. Epub 2006 Oct 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17077482 17077482]
[[Category: Perkinsus marinus]]
[[Category: Perkinsus marinus]]
[[Category: Single protein]]
[[Category: Asojo OA]]
[[Category: Superoxide dismutase]]
[[Category: Schott EJ]]
[[Category: Asojo, O A.]]
[[Category: Silva AM]]
[[Category: Schott, E J.]]
[[Category: Vasta GR]]
[[Category: Silva, A M.]]
[[Category: Vasta, G R.]]
[[Category: sod]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:27:06 2008''

Latest revision as of 16:44, 13 March 2024

Crystal structure of Superoxide dismutase from P. MarinusCrystal structure of Superoxide dismutase from P. Marinus

Structural highlights

2cw2 is a 2 chain structure with sequence from Perkinsus marinus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.86Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8ISJ0_9ALVE Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[RuleBase:RU000414]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2cw2, resolution 1.86Å

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