2ct8: Difference between revisions

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-[[Image:2ct8.png|left|200px]]
-{{STRUCTURE_2ct8|  PDB=2ct8  |  SCENE=  }}
+==Crystal structure of Aquifex aeolicus methionyl-tRNA synthetase complexed with tRNA(Met) and methionyl-adenylate anologue==
+<StructureSection load='2ct8' size='340' side='right'caption='[[2ct8]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-===Crystal structure of Aquifex aeolicus methionyl-tRNA synthetase complexed with tRNA(Met) and methionyl-adenylate anologue===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ct8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CT8 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_16155581}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSP:5-O-[(L-METHIONYL)-SULPHAMOYL]ADENOSINE'>MSP</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ct8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ct8 OCA], [https://pdbe.org/2ct8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ct8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ct8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ct8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ct8 TOPSAN]</span></td></tr>
-[[2ct8]] is a 4 chain structure of [[Aminoacyl tRNA Synthetase]] with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT8 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SYM_AQUAE SYM_AQUAE] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/2ct8_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ct8 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Aminoacyl tRNA Synthetase|Aminoacyl tRNA Synthetase]]
+*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:016155581</ref><references group="xtra"/>
 [[Category: Aquifex aeolicus]]
-[[Category: Methionine--tRNA ligase]]
+[[Category: Large Structures]]
-[[Category: Fukai, S.]]
+[[Category: Fukai S]]
-[[Category: Nakama, T.]]
+[[Category: Nakama T]]
-[[Category: Nakanishi, K.]]
+[[Category: Nakanishi K]]
-[[Category: Nureki, O.]]
+[[Category: Nureki O]]
-[[Category: Ogiso, Y.]]
+[[Category: Ogiso Y]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
-[[Category: Ligase]]
-[[Category: Ligase-rna complex]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]