2ag5: Difference between revisions

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New page: left|200px<br /> <applet load="2ag5" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ag5, resolution 1.84Å" /> '''Crystal Structure o...
 
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[[Image:2ag5.gif|left|200px]]<br />
<applet load="2ag5" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2ag5, resolution 1.84&Aring;" />
'''Crystal Structure of Human DHRS6'''<br />


==About this Structure==
==Crystal Structure of Human DHRS6==
2AG5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and NAD as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2AG5 OCA].  
<StructureSection load='2ag5' size='340' side='right'caption='[[2ag5]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ag5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AG5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ag5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ag5 OCA], [https://pdbe.org/2ag5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ag5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ag5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ag5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DHRS6_HUMAN DHRS6_HUMAN] Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ag/2ag5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ag5 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Delft, F.Von.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Kunde G]]
[[Category: Kunde, G.]]
[[Category: Lukacik P]]
[[Category: Lukacik, P.]]
[[Category: Oppermann U]]
[[Category: Oppermann, U.]]
[[Category: Papagrigoriou E]]
[[Category: Papagrigoriou, E.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Von Delft F]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: NAD]]
[[Category: SO4]]
[[Category: protein-co-factor complex ]]
[[Category: sgc]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:50:57 2007''

Latest revision as of 16:41, 13 March 2024

Crystal Structure of Human DHRS6Crystal Structure of Human DHRS6

Structural highlights

2ag5 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.84Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DHRS6_HUMAN Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2ag5, resolution 1.84Å

Drag the structure with the mouse to rotate

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OCA
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