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[[Image:2ag5.gif|left|200px]]


{{Structure
==Crystal Structure of Human DHRS6==
|PDB= 2ag5 |SIZE=350|CAPTION= <scene name='initialview01'>2ag5</scene>, resolution 1.84&Aring;
<StructureSection load='2ag5' size='340' side='right'caption='[[2ag5]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
<table><tr><td colspan='2'>[[2ag5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AG5 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
|GENE= DHRS6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ag5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ag5 OCA], [https://pdbe.org/2ag5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ag5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ag5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ag5 ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ag5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ag5 OCA], [http://www.ebi.ac.uk/pdbsum/2ag5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ag5 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/DHRS6_HUMAN DHRS6_HUMAN] Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).
 
== Evolutionary Conservation ==
'''Crystal Structure of Human DHRS6'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ag/2ag5_consurf.spt"</scriptWhenChecked>
2AG5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AG5 OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ag5 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Delft, F Von.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Kunde G]]
[[Category: Kunde, G.]]
[[Category: Lukacik P]]
[[Category: Lukacik, P.]]
[[Category: Oppermann U]]
[[Category: Oppermann, U.]]
[[Category: Papagrigoriou E]]
[[Category: Papagrigoriou, E.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Von Delft F]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: protein-co-factor complex]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:52:13 2008''

Latest revision as of 16:41, 13 March 2024

Crystal Structure of Human DHRS6Crystal Structure of Human DHRS6

Structural highlights

2ag5 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.84Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DHRS6_HUMAN Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2ag5, resolution 1.84Å

Drag the structure with the mouse to rotate

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