2af0: Difference between revisions

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-[[Image:2af0.gif|left|200px]]
-<!--
+==Structure of the Regulator of G-Protein Signaling Domain of RGS2==
-The line below this paragraph, containing "STRUCTURE_2af0", creates the "Structure Box" on the page.
+<StructureSection load='2af0' size='340' side='right'caption='[[2af0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2af0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AF0 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2af0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2af0 OCA], [https://pdbe.org/2af0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2af0 RCSB], [https://www.ebi.ac.uk/pdbsum/2af0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2af0 ProSAT]</span></td></tr>
-{{STRUCTURE_2af0|  PDB=2af0  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RGS2_HUMAN RGS2_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.<ref>PMID:11278586</ref> <ref>PMID:17901199</ref> <ref>PMID:7643615</ref> <ref>PMID:19736320</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/2af0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2af0 ConSurf].
+<div style="clear:both"></div>
-'''Structure of the Regulator of G-Protein Signaling Domain of RGS2'''
+==See Also==
+*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-AF0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AF0 OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.]]
+[[Category: Arrowsmith C]]
-[[Category: Delft, F Von.]]
+[[Category: Doyle DA]]
-[[Category: Doyle, D A.]]
+[[Category: Edwards A]]
-[[Category: Edwards, A.]]
+[[Category: Elkins JM]]
-[[Category: Elkins, J M.]]
+[[Category: Johannson C]]
-[[Category: Johannson, C.]]
+[[Category: Papagrigoriou E]]
-[[Category: Papagrigoriou, E.]]
+[[Category: Phillips C]]
-[[Category: Phillips, C.]]
+[[Category: Smee C]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Sundstrom M]]
-[[Category: Smee, C.]]
+[[Category: Von Delft F]]
-[[Category: Sundstrom, M.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
-[[Category: Helix]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:58:03 2008''