2ae3: Difference between revisions

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-[[Image:2ae3.png|left|200px]]
-{{STRUCTURE_2ae3|  PDB=2ae3  |  SCENE=  }}
+==Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism==
+<StructureSection load='2ae3' size='340' side='right'caption='[[2ae3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-===Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ae3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_sp._GK16 Pseudomonas sp. GK16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AE3 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_16446446}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ae3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ae3 OCA], [https://pdbe.org/2ae3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ae3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ae3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ae3 ProSAT]</span></td></tr>
-[[2ae3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp. Pseudomonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AE3 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/G7AC_PSEU7 G7AC_PSEU7] Catalyzes the deacylation of 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl-7-aminocephalosporanic acid or GL-7-ACA) to 7-aminocephalosporanic acid (7-ACA).<ref>PMID:2993240</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/2ae3_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ae3 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Cephalosporin acylase|Cephalosporin acylase]]
+*[[Cephalosporin acylase 3D structures|Cephalosporin acylase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:016446446</ref><ref group="xtra">PMID:019800869</ref><references group="xtra"/>
+__TOC__
-[[Category: Penicillin amidase]]
+</StructureSection>
-[[Category: Pseudomonas sp.]]
+[[Category: Large Structures]]
-[[Category: Cho, K J.]]
+[[Category: Pseudomonas sp. GK16]]
-[[Category: Kim, J K.]]
+[[Category: Cho KJ]]
-[[Category: Kim, K H.]]
+[[Category: Kim JK]]
-[[Category: Kim, S H.]]
+[[Category: Kim KH]]
-[[Category: Park, S S.]]
+[[Category: Kim SH]]
-[[Category: Ryu, E K.]]
+[[Category: Park SS]]
-[[Category: Shin, H J.]]
+[[Category: Ryu EK]]
-[[Category: Yang, I S.]]
+[[Category: Shin HJ]]
-[[Category: Autoproteolysis]]
+[[Category: Yang IS]]
-[[Category: Cephalosporin acylase]]
-[[Category: Hydrolase]]
-[[Category: Intermediate structure]]
-[[Category: Precursor activation]]