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[[Image:2adv.gif|left|200px]]


{{Structure
==Crystal Structures Of Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism==
|PDB= 2adv |SIZE=350|CAPTION= <scene name='initialview01'>2adv</scene>, resolution 2.244&Aring;
<StructureSection load='2adv' size='340' side='right'caption='[[2adv]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2adv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_sp._GK16 Pseudomonas sp. GK16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ADV FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Penicillin_amidase Penicillin amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.11 3.5.1.11] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.244&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2adv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adv OCA], [https://pdbe.org/2adv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2adv RCSB], [https://www.ebi.ac.uk/pdbsum/2adv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2adv ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=[[2ae3|2AE3]], [[2ae4|2AE4]], [[2ae5|2AE5]]
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adv OCA], [http://www.ebi.ac.uk/pdbsum/2adv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2adv RCSB]</span>
[https://www.uniprot.org/uniprot/G7AC_PSEU7 G7AC_PSEU7] Catalyzes the deacylation of 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl-7-aminocephalosporanic acid or GL-7-ACA) to 7-aminocephalosporanic acid (7-ACA).<ref>PMID:2993240</ref>
}}
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/2adv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2adv ConSurf].
<div style="clear:both"></div>


'''Crystal Structures Of Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism'''
==See Also==
 
*[[Cephalosporin acylase 3D structures|Cephalosporin acylase 3D structures]]
 
== References ==
==About this Structure==
<references/>
2ADV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_sp. Pseudomonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADV OCA].
__TOC__
[[Category: Penicillin amidase]]
</StructureSection>
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Pseudomonas sp.]]
[[Category: Pseudomonas sp. GK16]]
[[Category: Cho, K J.]]
[[Category: Cho KJ]]
[[Category: Kim, J K.]]
[[Category: Kim JK]]
[[Category: Kim, K H.]]
[[Category: Kim KH]]
[[Category: Kim, S H.]]
[[Category: Kim SH]]
[[Category: Park, S S.]]
[[Category: Park SS]]
[[Category: Ryu, E K.]]
[[Category: Ryu EK]]
[[Category: Shin, H J.]]
[[Category: Shin HJ]]
[[Category: Yang, I S.]]
[[Category: Yang IS]]
[[Category: autoproteolysis]]
[[Category: cephalosporin acylase]]
[[Category: intermediate structure]]
[[Category: precursor activation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:51:18 2008''

Latest revision as of 16:40, 13 March 2024

Crystal Structures Of Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanismCrystal Structures Of Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism

Structural highlights

2adv is a 3 chain structure with sequence from Pseudomonas sp. GK16. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.244Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

G7AC_PSEU7 Catalyzes the deacylation of 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl-7-aminocephalosporanic acid or GL-7-ACA) to 7-aminocephalosporanic acid (7-ACA).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Matsuda A, Komatsu KI. Molecular cloning and structure of the gene for 7 beta-(4-carboxybutanamido)cephalosporanic acid acylase from a Pseudomonas strain. J Bacteriol. 1985 Sep;163(3):1222-8. PMID:2993240

2adv, resolution 2.24Å

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