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==Structural Basis for Shikimate-binding Specificity of Helicobacter pylori Shikimate Kinase== | |||
<StructureSection load='1zui' size='340' side='right'caption='[[1zui]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1zui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZUI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SKM:(3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>SKM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zui OCA], [https://pdbe.org/1zui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zui RCSB], [https://www.ebi.ac.uk/pdbsum/1zui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zui ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AROK_HELPY AROK_HELPY] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:16291688</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zu/1zui_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zui ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Shikimate kinase 3D structures|Shikimate kinase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
[[ | </StructureSection> | ||
[[Category: Helicobacter pylori 26695]] | |||
== | [[Category: Large Structures]] | ||
< | [[Category: Chang YN]] | ||
[[Category: Helicobacter pylori]] | [[Category: Cheng WC]] | ||
[[Category: | [[Category: Wang WC]] | ||
[[Category: Chang | |||
[[Category: Cheng | |||
[[Category: Wang | |||
Latest revision as of 16:39, 13 March 2024
Structural Basis for Shikimate-binding Specificity of Helicobacter pylori Shikimate KinaseStructural Basis for Shikimate-binding Specificity of Helicobacter pylori Shikimate Kinase
Structural highlights
FunctionAROK_HELPY Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See AlsoReferences
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