1zcd: Difference between revisions

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-[[Image:1zcd.png|left|200px]]
-<!--
+==Crystal structure of the Na+/H+ antiporter NhaA==
-The line below this paragraph, containing "STRUCTURE_1zcd", creates the "Structure Box" on the page.
+<StructureSection load='1zcd' size='340' side='right'caption='[[1zcd]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1zcd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The December 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Complex I''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_12 10.2210/rcsb_pdb/mom_2011_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZCD FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.45&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zcd OCA], [https://pdbe.org/1zcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zcd RCSB], [https://www.ebi.ac.uk/pdbsum/1zcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zcd ProSAT]</span></td></tr>
-{{STRUCTURE_1zcd|  PDB=1zcd  |  SCENE=  }}
+</table>
+== Function ==
-===Crystal structure of the Na+/H+ antiporter NhaA===
+[https://www.uniprot.org/uniprot/NHAA_ECOLI NHAA_ECOLI] Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 2 H(+) per Na(+). Can mediate sodium uptake when a transmembrane pH gradient is applied. Active at alkaline pH. Activity is strongly down-regulated below pH 6.5.<ref>PMID:1645730</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-<!--
+Check<jmol>
-The line below this paragraph, {{ABSTRACT_PUBMED_15988517}}, adds the Publication Abstract to the page
+  <jmolCheckbox>
-(as it appears on PubMed at http://www.pubmed.gov), where 15988517 is the PubMed ID number.
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/1zcd_consurf.spt"</scriptWhenChecked>
--->
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-{{ABSTRACT_PUBMED_15988517}}
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==About this Structure==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zcd ConSurf].
-[[1zcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The December 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Complex I''  by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_12 10.2210/rcsb_pdb/mom_2011_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZCD OCA].
+<div style="clear:both"></div>
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:015988517</ref><ref group="xtra">PMID:016919297</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Complex I]]
 [[Category: Escherichia coli]]
+[[Category: Large Structures]]
 [[Category: RCSB PDB Molecule of the Month]]
-[[Category: Hunte, C.]]
+[[Category: Hunte C]]
-[[Category: Michel, H.]]
+[[Category: Michel H]]
-[[Category: Padan, E.]]
+[[Category: Padan E]]
-[[Category: Rimon, A.]]
+[[Category: Rimon A]]
-[[Category: Screpanti, E.]]
+[[Category: Screpanti E]]
-[[Category: Venturi, M.]]
+[[Category: Venturi M]]
-[[Category: Antiporter]]
-[[Category: Membrane protein]]