1z6a: Difference between revisions

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[[Image:1z6a.gif|left|200px]]


{{Structure
==Sulfolobus solfataricus SWI2/SNF2 ATPase core domain==
|PDB= 1z6a |SIZE=350|CAPTION= <scene name='initialview01'>1z6a</scene>, resolution 3.0&Aring;
<StructureSection load='1z6a' size='340' side='right'caption='[[1z6a]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
<table><tr><td colspan='2'>[[1z6a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z6A FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z6a OCA], [https://pdbe.org/1z6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z6a RCSB], [https://www.ebi.ac.uk/pdbsum/1z6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z6a ProSAT]</span></td></tr>
|RELATEDENTRY=[[1z5z|1Z5Z]], [[1z63|1Z63]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z6a OCA], [http://www.ebi.ac.uk/pdbsum/1z6a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z6a RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/Q97XQ7_SACS2 Q97XQ7_SACS2]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/1z6a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z6a ConSurf].
<div style="clear:both"></div>


'''Sulfolobus solfataricus SWI2/SNF2 ATPase core domain'''
==See Also==
 
*[[Helicase 3D structures|Helicase 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
SWI2/SNF2 ATPases remodel chromatin or other DNA:protein complexes by a poorly understood mechanism that involves ATP-dependent DNA translocation and generation of superhelical torsion. Crystal structures of a dsDNA-translocating SWI2/SNF2 ATPase core from Sulfolobus solfataricus reveal two helical SWI2/SNF2 specific subdomains, fused to a DExx box helicase-related ATPase core. Fully base paired duplex DNA binds along a central cleft via both minor groove strands, indicating that SWI2/SNF2 ATPases travel along the dsDNA minor groove without strand separation. A structural switch, linking DNA binding and the active site DExx motif, may account for the stimulation of ATPase activity by dsDNA. Our results suggest that torque in remodeling processes is generated by an ATP-driven screw motion of DNA along the active site cleft. The structures also redefine SWI2/SNF2 functional motifs and uncover unexpected structural correlation of mutations in Cockayne and X-linked mental retardation syndromes.
[[Category: Large Structures]]
 
[[Category: Saccharolobus solfataricus P2]]
==About this Structure==
[[Category: Duerr H]]
1Z6A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus_p2 Sulfolobus solfataricus p2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6A OCA].
[[Category: Hickmann V]]
 
[[Category: Hopfner KP]]
==Reference==
[[Category: Koerner C]]
X-ray structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase core and its complex with DNA., Durr H, Korner C, Muller M, Hickmann V, Hopfner KP, Cell. 2005 May 6;121(3):363-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15882619 15882619]
[[Category: Mueller M]]
[[Category: Single protein]]
[[Category: Sulfolobus solfataricus p2]]
[[Category: Duerr, H.]]
[[Category: Hickmann, V.]]
[[Category: Hopfner, K P.]]
[[Category: Koerner, C.]]
[[Category: Mueller, M.]]
[[Category: hydrolase]]
[[Category: recombination]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:29:42 2008''

Latest revision as of 16:39, 13 March 2024

Sulfolobus solfataricus SWI2/SNF2 ATPase core domainSulfolobus solfataricus SWI2/SNF2 ATPase core domain

Structural highlights

1z6a is a 1 chain structure with sequence from Saccharolobus solfataricus P2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q97XQ7_SACS2

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1z6a, resolution 3.00Å

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