1x2j: Difference between revisions

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-{{Seed}}
-[[Image:1x2j.png|left|200px]]
-<!--
+==Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2==
-The line below this paragraph, containing "STRUCTURE_1x2j", creates the "Structure Box" on the page.
+<StructureSection load='1x2j' size='340' side='right'caption='[[1x2j]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1x2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X2J FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1x2j|  PDB=1x2j  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x2j OCA], [https://pdbe.org/1x2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x2j RCSB], [https://www.ebi.ac.uk/pdbsum/1x2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x2j ProSAT], [https://www.topsan.org/Proteins/RSGI/1x2j TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/1x2j_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x2j ConSurf].
+<div style="clear:both"></div>
-===Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2===
+==See Also==
+*[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_16507366}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 16507366 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Large Structures]]
-{{ABSTRACT_PUBMED_16507366}}
-==About this Structure==
-X2J is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X2J OCA].
-==Reference==
-Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer., Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, Kang MI, Kobayashi A, Yokoyama S, Yamamoto M, Mol Cell. 2006 Mar 3;21(5):689-700. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16507366 16507366]
 [[Category: Mus musculus]]
-[[Category: Kang, M I.]]
+[[Category: Kang M-I]]
-[[Category: Kobayashi, A.]]
+[[Category: Kobayashi A]]
-[[Category: Nakamura, Y.]]
+[[Category: Nakamura Y]]
-[[Category: Ohta, T.]]
+[[Category: Ohta T]]
-[[Category: Ohtsuji, M.]]
+[[Category: Ohtsuji M]]
-[[Category: Padmanabhan, B.]]
+[[Category: Padmanabhan B]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Scharlock M]]
-[[Category: Scharlock, M.]]
+[[Category: Tong KI]]
-[[Category: Tong, K I.]]
+[[Category: Yamamoto M]]
-[[Category: Yamamoto, M.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
-[[Category: Beta propeller]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nppsfa]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 12:50:40 2008''