1ww5: Difference between revisions

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{{Seed}}
[[Image:1ww5.png|left|200px]]


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==Agrocybe cylindracea galectin complexed with 3'-sulfonyl lactose==
The line below this paragraph, containing "STRUCTURE_1ww5", creates the "Structure Box" on the page.
<StructureSection load='1ww5' size='340' side='right'caption='[[1ww5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ww5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrocybe_cylindracea Agrocybe cylindracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WW5 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PRD_900068:lactose-3-sulfate'>PRD_900068</scene>, <scene name='pdbligand=SGA:O3-SULFONYLGALACTOSE'>SGA</scene></td></tr>
{{STRUCTURE_1ww5| PDB=1ww5 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ww5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ww5 OCA], [https://pdbe.org/1ww5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ww5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ww5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ww5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ATLE_CYCAE ATLE_CYCAE] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells. Binds N-acetylneuraminyl lactose (N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose) (PubMed:16051274).<ref>PMID:12757412</ref> <ref>PMID:16051274</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/1ww5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ww5 ConSurf].
<div style="clear:both"></div>


===Agrocybe cylindracea galectin complexed with 3'-sulfonyl lactose===
==See Also==
 
*[[Galectin 3D structures|Galectin 3D structures]]
 
== References ==
<!--
<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 16051274 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_16051274}}
 
==About this Structure==
1WW5 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Agrocybe_cylindracea Agrocybe cylindracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WW5 OCA].
 
==Reference==
<ref group="xtra">PMID:16051274</ref><references group="xtra"/>
[[Category: Agrocybe cylindracea]]
[[Category: Agrocybe cylindracea]]
[[Category: Ban, M.]]
[[Category: Large Structures]]
[[Category: Demirkan, E.]]
[[Category: Ban M]]
[[Category: Mikami, B.]]
[[Category: Demirkan E]]
[[Category: Utsumi, S.]]
[[Category: Mikami B]]
[[Category: Yagi, F.]]
[[Category: Utsumi S]]
[[Category: Yoon, H J.]]
[[Category: Yagi F]]
[[Category: 3'-sulfated lactose]]
[[Category: Yoon HJ]]
[[Category: Agrocybe cylindracea galectin]]
[[Category: Carbohydrate recognition domain]]
[[Category: Fungal galectin]]
[[Category: X-ray crystallographic analysis]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:47:56 2009''

Latest revision as of 16:34, 13 March 2024

Agrocybe cylindracea galectin complexed with 3'-sulfonyl lactoseAgrocybe cylindracea galectin complexed with 3'-sulfonyl lactose

Structural highlights

1ww5 is a 4 chain structure with sequence from Agrocybe cylindracea. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ATLE_CYCAE Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells. Binds N-acetylneuraminyl lactose (N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose) (PubMed:16051274).[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Zhao C, Sun H, Tong X, Qi Y. An antitumour lectin from the edible mushroom Agrocybe aegerita. Biochem J. 2003 Sep 1;374(Pt 2):321-7. PMID:12757412 doi:10.1042/BJ20030300
  2. ↑ Ban M, Yoon HJ, Demirkan E, Utsumi S, Mikami B, Yagi F. Structural basis of a fungal galectin from Agrocybe cylindracea for recognizing sialoconjugate. J Mol Biol. 2005 Aug 26;351(4):695-706. PMID:16051274 doi:10.1016/j.jmb.2005.06.045

1ww5, resolution 2.20Å

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