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==Crystal structure of protein GI:29375081, unknown member of enolase superfamily from enterococcus faecalis V583== | |||
<StructureSection load='1wue' size='340' side='right'caption='[[1wue]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1wue]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUE FirstGlance]. <br> | |||
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wue OCA], [https://pdbe.org/1wue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wue RCSB], [https://www.ebi.ac.uk/pdbsum/1wue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wue ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1wue TOPSAN]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MENC_ENTFA MENC_ENTFA] Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:24872444). Also acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-L-phenylglycine (PubMed:24872444). Since the gene is encoded in a menaquinone synthesis operon, OSB synthase is probably the physiological activity. A pathway that requires NSAR activity has not been identified in this species, so whether NSAR is also a biological activity is unknown (PubMed:24872444).<ref>PMID:24872444</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/1wue_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wue ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Mandelate racemase/muconate lactonizing enzyme 3D structures|Mandelate racemase/muconate lactonizing enzyme 3D structures]] | |||
== References == | |||
== | <references/> | ||
__TOC__ | |||
[[Category: Enterococcus faecalis]] | </StructureSection> | ||
[[Category: | [[Category: Enterococcus faecalis V583]] | ||
[[Category: Almo | [[Category: Large Structures]] | ||
[[Category: Burley | [[Category: Almo SC]] | ||
[[Category: Fedorov | [[Category: Burley SK]] | ||
[[Category: Fedorov | [[Category: Fedorov AA]] | ||
[[Category: Gerlt | [[Category: Fedorov EV]] | ||
[[Category: Gerlt JA]] | |||
[[Category: Yew | [[Category: Yew WS]] | ||
Latest revision as of 16:34, 13 March 2024
Crystal structure of protein GI:29375081, unknown member of enolase superfamily from enterococcus faecalis V583Crystal structure of protein GI:29375081, unknown member of enolase superfamily from enterococcus faecalis V583
Structural highlights
FunctionMENC_ENTFA Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:24872444). Also acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-L-phenylglycine (PubMed:24872444). Since the gene is encoded in a menaquinone synthesis operon, OSB synthase is probably the physiological activity. A pathway that requires NSAR activity has not been identified in this species, so whether NSAR is also a biological activity is unknown (PubMed:24872444).[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See AlsoReferences
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