1wu9: Difference between revisions

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[[Image:1wu9.png|left|200px]]


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==Crystal structure of the C-terminal domain of the end-binding protein 1 (EB1)==
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<StructureSection load='1wu9' size='340' side='right'caption='[[1wu9]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1wu9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WU9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WU9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wu9 OCA], [https://pdbe.org/1wu9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wu9 RCSB], [https://www.ebi.ac.uk/pdbsum/1wu9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wu9 ProSAT]</span></td></tr>
{{STRUCTURE_1wu9| PDB=1wu9 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/MARE1_HUMAN MARE1_HUMAN] Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.<ref>PMID:12388762</ref> <ref>PMID:21646404</ref> <ref>PMID:16109370</ref> <ref>PMID:19632184</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/1wu9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wu9 ConSurf].
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===Crystal structure of the C-terminal domain of the end-binding protein 1 (EB1)===
==See Also==
 
*[[End-binding protein|End-binding protein]]
 
*[[Microtubule-associated protein 3D structures|Microtubule-associated protein 3D structures]]
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== References ==
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</StructureSection>
{{ABSTRACT_PUBMED_15616574}}
 
==About this Structure==
1WU9 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WU9 OCA].
 
==Reference==
<ref group="xtra">PMID:15616574</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Honnappa, S.]]
[[Category: Large Structures]]
[[Category: John, C M.]]
[[Category: Honnappa S]]
[[Category: Kostrewa, D.]]
[[Category: John CM]]
[[Category: Steinmetz, M O.]]
[[Category: Kostrewa D]]
[[Category: Winkler, F K.]]
[[Category: Steinmetz MO]]
[[Category: Apc/dynactin binding domain]]
[[Category: Winkler FK]]
[[Category: Coiled coil]]
[[Category: Eb1-like structural motif]]
 
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