1wu9: Difference between revisions

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[[Image:1wu9.png|left|200px]]


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==Crystal structure of the C-terminal domain of the end-binding protein 1 (EB1)==
The line below this paragraph, containing "STRUCTURE_1wu9", creates the "Structure Box" on the page.
<StructureSection load='1wu9' size='340' side='right'caption='[[1wu9]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1wu9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WU9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WU9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wu9 OCA], [https://pdbe.org/1wu9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wu9 RCSB], [https://www.ebi.ac.uk/pdbsum/1wu9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wu9 ProSAT]</span></td></tr>
{{STRUCTURE_1wu9| PDB=1wu9 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/MARE1_HUMAN MARE1_HUMAN] Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.<ref>PMID:12388762</ref> <ref>PMID:21646404</ref> <ref>PMID:16109370</ref> <ref>PMID:19632184</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/1wu9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wu9 ConSurf].
<div style="clear:both"></div>


===Crystal structure of the C-terminal domain of the end-binding protein 1 (EB1)===
==See Also==
 
*[[End-binding protein|End-binding protein]]
 
*[[Microtubule-associated protein 3D structures|Microtubule-associated protein 3D structures]]
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== References ==
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</StructureSection>
{{ABSTRACT_PUBMED_15616574}}
 
==About this Structure==
1WU9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WU9 OCA].
 
==Reference==
Structural insights into the EB1-APC interaction., Honnappa S, John CM, Kostrewa D, Winkler FK, Steinmetz MO, EMBO J. 2005 Jan 26;24(2):261-9. Epub 2004 Dec 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15616574 15616574]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Honnappa, S.]]
[[Category: Honnappa S]]
[[Category: John, C M.]]
[[Category: John CM]]
[[Category: Kostrewa, D.]]
[[Category: Kostrewa D]]
[[Category: Steinmetz, M O.]]
[[Category: Steinmetz MO]]
[[Category: Winkler, F K.]]
[[Category: Winkler FK]]
[[Category: Apc/dynactin binding domain]]
[[Category: Coiled coil]]
[[Category: Eb1-like structural motif]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:43:44 2008''

Latest revision as of 16:34, 13 March 2024

Crystal structure of the C-terminal domain of the end-binding protein 1 (EB1)Crystal structure of the C-terminal domain of the end-binding protein 1 (EB1)

Structural highlights

1wu9 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.54Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MARE1_HUMAN Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.[1] [2] [3] [4]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Askham JM, Vaughan KT, Goodson HV, Morrison EE. Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. Mol Biol Cell. 2002 Oct;13(10):3627-45. PMID:12388762 doi:10.1091/mbc.E02-01-0061
  2. ↑ van der Vaart B, Manatschal C, Grigoriev I, Olieric V, Gouveia SM, Bjelic S, Demmers J, Vorobjev I, Hoogenraad CC, Steinmetz MO, Akhmanova A. SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. J Cell Biol. 2011 Jun 13;193(6):1083-99. Epub 2011 Jun 6. PMID:21646404 doi:10.1083/jcb.201012179
  3. ↑ Hayashi I, Wilde A, Mal TK, Ikura M. Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex. Mol Cell. 2005 Aug 19;19(4):449-60. PMID:16109370 doi:10.1016/j.molcel.2005.06.034
  4. ↑ Honnappa S, Gouveia SM, Weisbrich A, Damberger FF, Bhavesh NS, Jawhari H, Grigoriev I, van Rijssel FJ, Buey RM, Lawera A, Jelesarov I, Winkler FK, Wuthrich K, Akhmanova A, Steinmetz MO. An EB1-binding motif acts as a microtubule tip localization signal. Cell. 2009 Jul 23;138(2):366-76. PMID:19632184 doi:S0092-8674(09)00638-2

1wu9, resolution 1.54Å

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