1wt2: Difference between revisions

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-[[Image:1wt2.png|left|200px]]
-<!--
+==Mutant human ABO(H) blood group glycosyltransferase A with bound UDP and inhibitor==
-The line below this paragraph, containing "STRUCTURE_1wt2", creates the "Structure Box" on the page.
+<StructureSection load='1wt2' size='340' side='right'caption='[[1wt2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1wt2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WT2 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
-{{STRUCTURE_1wt2|  PDB=1wt2  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wt2 OCA], [https://pdbe.org/1wt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wt2 RCSB], [https://www.ebi.ac.uk/pdbsum/1wt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wt2 ProSAT]</span></td></tr>
+</table>
-===Mutant human ABO(H) blood group glycosyltransferase A with bound UDP and inhibitor===
+== Function ==
+[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_15475562}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 15475562 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/1wt2_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_15475562}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-[[1wt2]] is a 1 chain structure of [[Galactosyltransferase]] and [[Glycosyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WT2 OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wt2 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Galactosyltransferase|Galactosyltransferase]]
+*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
-*[[Glycosyltransferase|Glycosyltransferase]]
+__TOC__
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:015475562</ref><references group="xtra"/>
-[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]
 [[Category: Homo sapiens]]
-[[Category: Barry, C H.]]
+[[Category: Large Structures]]
-[[Category: Blancher, A.]]
+[[Category: Barry CH]]
-[[Category: Borisova, S N.]]
+[[Category: Blancher A]]
-[[Category: Evans, S V.]]
+[[Category: Borisova SN]]
-[[Category: Lee, H J.]]
+[[Category: Evans SV]]
-[[Category: Palcic, M M.]]
+[[Category: Lee HJ]]
-[[Category: Seto, N O.L.]]
+[[Category: Palcic MM]]
-[[Category: Zheng, R B.]]
+[[Category: Seto NOL]]
-[[Category: Transferase]]
+[[Category: Zheng RB]]