1wp8: Difference between revisions

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-[[Image:1wp8.gif|left|200px]]
-<!--
+==crystal structure of Hendra Virus fusion core==
-The line below this paragraph, containing "STRUCTURE_1wp8", creates the "Structure Box" on the page.
+<StructureSection load='1wp8' size='340' side='right'caption='[[1wp8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1wp8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hendra_henipavirus Hendra henipavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WP8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wp8 OCA], [https://pdbe.org/1wp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wp8 RCSB], [https://www.ebi.ac.uk/pdbsum/1wp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wp8 ProSAT]</span></td></tr>
-{{STRUCTURE_1wp8|  PDB=1wp8  |  SCENE=  }}
+</table>
+== Function ==
-'''crystal structure of Hendra Virus fusion core'''
+[https://www.uniprot.org/uniprot/FUS_HENDH FUS_HENDH] Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with HN at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Hendra henipavirus]]
-WP8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hendra_virus Hendra virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WP8 OCA].
+[[Category: Large Structures]]
-[[Category: Hendra virus]]
+[[Category: Bai Z]]
-[[Category: Single protein]]
+[[Category: Gao GF]]
-[[Category: Bai, Z.]]
+[[Category: Liu Y]]
-[[Category: Gao, G F.]]
+[[Category: Lou Z]]
-[[Category: Liu, Y.]]
+[[Category: Rao Z]]
-[[Category: Lou, Z.]]
+[[Category: Su N]]
-[[Category: Rao, Z.]]
+[[Category: Xu Y]]
-[[Category: Su, N.]]
-[[Category: Xu, Y.]]
-[[Category: Crystal structure]]
-[[Category: Fusion core]]
-[[Category: Hendra virus]]
-[[Category: Heptad repeat]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:58:26 2008''