1wp8: Difference between revisions

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-[[Image:1wp8.gif|left|200px]]<br /><applet load="1wp8" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="1wp8, resolution 2.2&Aring;" />
-'''crystal structure of Hendra Virus fusion core'''<br />
-==About this Structure==
+==crystal structure of Hendra Virus fusion core==
-WP8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hendra_virus Hendra virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WP8 OCA].
+<StructureSection load='1wp8' size='340' side='right'caption='[[1wp8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-[[Category: Hendra virus]]
+== Structural highlights ==
-[[Category: Single protein]]
+<table><tr><td colspan='2'>[[1wp8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hendra_henipavirus Hendra henipavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WP8 FirstGlance]. <br>
-[[Category: Bai, Z.]]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-[[Category: Gao, G F.]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wp8 OCA], [https://pdbe.org/1wp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wp8 RCSB], [https://www.ebi.ac.uk/pdbsum/1wp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wp8 ProSAT]</span></td></tr>
-[[Category: Liu, Y.]]
+</table>
-[[Category: Lou, Z.]]
+== Function ==
-[[Category: Rao, Z.]]
+[https://www.uniprot.org/uniprot/FUS_HENDH FUS_HENDH] Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with HN at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).
-[[Category: Su, N.]]
+__TOC__
-[[Category: Xu, Y.]]
+</StructureSection>
-[[Category: crystal structure]]
+[[Category: Hendra henipavirus]]
-[[Category: fusion core]]
+[[Category: Large Structures]]
-[[Category: hendra virus]]
+[[Category: Bai Z]]
-[[Category: heptad repeat]]
+[[Category: Gao GF]]
+[[Category: Liu Y]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:46:55 2008''
+[[Category: Lou Z]]
+[[Category: Rao Z]]
+[[Category: Su N]]
+[[Category: Xu Y]]