1wm0: Difference between revisions

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-[[Image:1wm0.png|left|200px]]
-<!--
+==PPARgamma in complex with a 2-BABA compound==
-The line below this paragraph, containing "STRUCTURE_1wm0", creates the "Structure Box" on the page.
+<StructureSection load='1wm0' size='340' side='right'caption='[[1wm0]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1wm0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WM0 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLB:2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC+ACID'>PLB</scene></td></tr>
-{{STRUCTURE_1wm0|  PDB=1wm0  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wm0 OCA], [https://pdbe.org/1wm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wm0 RCSB], [https://www.ebi.ac.uk/pdbsum/1wm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wm0 ProSAT]</span></td></tr>
+</table>
-===PPARgamma in complex with a 2-BABA compound===
+== Disease ==
+[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.  Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref>   Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[https://omim.org/entry/604367 604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref>   Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
+== Function ==
-<!--
+[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_15258145}}, adds the Publication Abstract to the page
+== Evolutionary Conservation ==
-(as it appears on PubMed at http://www.pubmed.gov), where 15258145 is the PubMed ID number.
+[[Image:Consurf_key_small.gif|200px|right]]
--->
+Check<jmol>
-{{ABSTRACT_PUBMED_15258145}}
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/1wm0_consurf.spt"</scriptWhenChecked>
-==About this Structure==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[1wm0]] is a 2 chain structure of [[Peroxisome Proliferator-Activated Receptors]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WM0 OCA].
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wm0 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Peroxisome Proliferator-Activated Receptors|Peroxisome Proliferator-Activated Receptors]]
+*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:015258145</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Gustavsson, A L.]]
+[[Category: Large Structures]]
-[[Category: Jendeberg, L.]]
+[[Category: Mus musculus]]
-[[Category: Ostberg, T.]]
+[[Category: Gustavsson AL]]
-[[Category: Selen, G.]]
+[[Category: Jendeberg L]]
-[[Category: Sundbom, M.]]
+[[Category: Ostberg T]]
-[[Category: Svensson, S.]]
+[[Category: Selen G]]
-[[Category: Sydow-Backman, M.]]
+[[Category: Sundbom M]]
-[[Category: Thor, M.]]
+[[Category: Svensson S]]
-[[Category: Uppenberg, J.]]
+[[Category: Sydow-Backman M]]
-[[Category: Three-layer helical domain]]
+[[Category: Thor M]]
-[[Category: Transcription-signaling protein complex]]
+[[Category: Uppenberg J]]