1wdf: Difference between revisions

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-{{Seed}}
-[[Image:1wdf.png|left|200px]]
-<!--
+==crystal structure of MHV spike protein fusion core==
-The line below this paragraph, containing "STRUCTURE_1wdf", creates the "Structure Box" on the page.
+<StructureSection load='1wdf' size='340' side='right'caption='[[1wdf]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1wdf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_hepatitis_virus_strain_A59 Murine hepatitis virus strain A59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WDF FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wdf OCA], [https://pdbe.org/1wdf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wdf RCSB], [https://www.ebi.ac.uk/pdbsum/1wdf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wdf ProSAT]</span></td></tr>
-{{STRUCTURE_1wdf|  PDB=1wdf  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SPIKE_CVMA5 SPIKE_CVMA5] S1 attaches the virion to the cell membrane by interacting with murine CEACAM1, initiating the infection.<ref>PMID:16014947</ref>   S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Presumably interacts with target cell lipid raft after cell attachment.<ref>PMID:16014947</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wd/1wdf_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wdf ConSurf].
+<div style="clear:both"></div>
-===crystal structure of MHV spike protein fusion core===
+==See Also==
+*[[Sandbox 3001|Sandbox 3001]]
+*[[Spike protein 3D structures|Spike protein 3D structures]]
-<!--
+== References ==
-The line below this paragraph, {{ABSTRACT_PUBMED_15123674}}, adds the Publication Abstract to the page
+<references/>
-(as it appears on PubMed at http://www.pubmed.gov), where 15123674 is the PubMed ID number.
+__TOC__
--->
+</StructureSection>
-{{ABSTRACT_PUBMED_15123674}}
+[[Category: Large Structures]]
+[[Category: Murine hepatitis virus strain A59]]
-==About this Structure==
+[[Category: Bai Z]]
-WDF is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Murine_hepatitis_virus Murine hepatitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WDF OCA].
+[[Category: Gao GF]]
+[[Category: Li X]]
-==Reference==
+[[Category: Liu Y]]
-<ref group="xtra">PMID:15123674</ref><references group="xtra"/>
+[[Category: Lou Z]]
-[[Category: Murine hepatitis virus]]
+[[Category: Qin L]]
-[[Category: Bai, Z.]]
+[[Category: Rao Z]]
-[[Category: Gao, G F.]]
+[[Category: Tien P]]
-[[Category: Li, X.]]
+[[Category: Xu Y]]
-[[Category: Liu, Y.]]
-[[Category: Lou, Z.]]
-[[Category: Qin, L.]]
-[[Category: Rao, Z.]]
-[[Category: Tien, P.]]
-[[Category: Xu, Y.]]
-[[Category: Coiled coil]]
-[[Category: Coronavirus]]
-[[Category: Crystal structure]]
-[[Category: Fusion core]]
-[[Category: Heptad repeat]]
-[[Category: Mhv]]
-[[Category: Viral entry]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:38:28 2009''