1u07: Difference between revisions
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==Crystal Structure of the 92-residue C-term. part of TonB with significant structural changes compared to shorter fragments== | |||
<StructureSection load='1u07' size='340' side='right'caption='[[1u07]], [[Resolution|resolution]] 1.13Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1u07]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U07 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.13Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u07 OCA], [https://pdbe.org/1u07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u07 RCSB], [https://www.ebi.ac.uk/pdbsum/1u07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u07 ProSAT]</span></td></tr> | |||
== | </table> | ||
[[1u07]] is a 2 chain structure with sequence from [ | == Function == | ||
[https://www.uniprot.org/uniprot/TONB_ECOLI TONB_ECOLI] Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy-dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u0/1u07_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u07 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[TonB|TonB]] | *[[TonB|TonB]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Diederichs | [[Category: Large Structures]] | ||
[[Category: Howard | [[Category: Diederichs K]] | ||
[[Category: Killig | [[Category: Howard SP]] | ||
[[Category: Koedding | [[Category: Killig F]] | ||
[[Category: Polzer | [[Category: Koedding J]] | ||
[[Category: Welte | [[Category: Polzer P]] | ||
[[Category: Welte W]] | |||