1tq2: Difference between revisions

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-[[Image:1tq2.png|left|200px]]
-<!--
+==Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases==
-The line below this paragraph, containing "STRUCTURE_1tq2", creates the "Structure Box" on the page.
+<StructureSection load='1tq2' size='340' side='right'caption='[[1tq2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1tq2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQ2 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
-{{STRUCTURE_1tq2|  PDB=1tq2  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq2 OCA], [https://pdbe.org/1tq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tq2 RCSB], [https://www.ebi.ac.uk/pdbsum/1tq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tq2 ProSAT]</span></td></tr>
+</table>
-===Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases===
+== Function ==
+[https://www.uniprot.org/uniprot/IIGP1_MOUSE IIGP1_MOUSE] GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.<ref>PMID:11907101</ref> <ref>PMID:16304607</ref> <ref>PMID:19242543</ref> <ref>PMID:12732635</ref>
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_15350217}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 15350217 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tq2_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_15350217}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-[[1tq2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ2 OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tq2 ConSurf].
+<div style="clear:both"></div>
-==Reference==
+== References ==
-<ref group="xtra">PMID:15350217</ref><ref group="xtra">PMID:12732635</ref><references group="xtra"/>
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Ghosh, A.]]
+[[Category: Ghosh A]]
-[[Category: Herrmann, C.]]
+[[Category: Herrmann C]]
-[[Category: Howard, J.]]
+[[Category: Howard J]]
-[[Category: Uthaiah, R.]]
+[[Category: Uthaiah R]]
-[[Category: Wolf, E.]]
+[[Category: Wolf E]]
-[[Category: Crystal structure]]
-[[Category: Dimer]]
-[[Category: Gtpase]]
-[[Category: Immunology]]
-[[Category: Interferon gamma]]
-[[Category: Signaling protein]]