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[[Image:1rfj.gif|left|200px]]


{{Structure
==Crystal Structure of Potato Calmodulin PCM6==
|PDB= 1rfj |SIZE=350|CAPTION= <scene name='initialview01'>1rfj</scene>, resolution 2.00&Aring;
<StructureSection load='1rfj' size='340' side='right'caption='[[1rfj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
<table><tr><td colspan='2'>[[1rfj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Solanum_tuberosum Solanum tuberosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RFJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RFJ FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE= PCM6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4113 Solanum tuberosum])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rfj OCA], [https://pdbe.org/1rfj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rfj RCSB], [https://www.ebi.ac.uk/pdbsum/1rfj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rfj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CALM5_SOLTU CALM5_SOLTU] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/1rfj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rfj ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of Potato Calmodulin PCM6'''
==See Also==
 
*[[Calmodulin 3D structures|Calmodulin 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The crystal structure of a potato calmodulin (PCM6) was solved by molecular replacement and refined to a crystallographic R factor of 22.8% (R(free) = 25.0%) using X-ray diffraction data in the resolution range 8.0-2.0 A. This is the first report of the three-dimensional structure of a plant Ca(2+)-calmodulin. PCM6 crystallizes in a crystal form that belongs to space group P2(1)2(1)2(1), which is different to that of most other calmodulin crystals. The main structural difference between PCM6 and the other calmodulins is in the central helix region and appears to be caused by crystal packing. The surface properties of PCM6 molecules were compared with those of animal calmodulins, which provided an explanation for the unique crystal-packing state of PCM6.
[[Category: Large Structures]]
 
==About this Structure==
1RFJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Solanum_tuberosum Solanum tuberosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RFJ OCA].
 
==Reference==
Structure of potato calmodulin PCM6: the first report of the three-dimensional structure of a plant calmodulin., Yun CH, Bai J, Sun DY, Cui DF, Chang WR, Liang DC, Acta Crystallogr D Biol Crystallogr. 2004 Jul;60(Pt 7):1214-9. Epub 2004, Jun 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15213382 15213382]
[[Category: Single protein]]
[[Category: Solanum tuberosum]]
[[Category: Solanum tuberosum]]
[[Category: Chang, W R.]]
[[Category: Chang WR]]
[[Category: Liang, D C.]]
[[Category: Liang DC]]
[[Category: Yun, C H.]]
[[Category: Yun CH]]
[[Category: CA]]
[[Category: MPD]]
[[Category: crystal structure]]
[[Category: pcm6]]
[[Category: plant calmodulin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:50:54 2008''

Latest revision as of 16:29, 13 March 2024

Crystal Structure of Potato Calmodulin PCM6Crystal Structure of Potato Calmodulin PCM6

Structural highlights

1rfj is a 1 chain structure with sequence from Solanum tuberosum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CALM5_SOLTU Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1rfj, resolution 2.00Å

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