1q1c: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1q1c.png|left|200px]]
-<!--
+==Crystal structure of N(1-260) of human FKBP52==
-The line below this paragraph, containing "STRUCTURE_1q1c", creates the "Structure Box" on the page.
+<StructureSection load='1q1c' size='340' side='right'caption='[[1q1c]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1q1c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q1C FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-{{STRUCTURE_1q1c|  PDB=1q1c  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1c OCA], [https://pdbe.org/1q1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q1c RCSB], [https://www.ebi.ac.uk/pdbsum/1q1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1c ProSAT]</span></td></tr>
+</table>
-===Crystal structure of N(1-260) of human FKBP52===
+== Function ==
+[https://www.uniprot.org/uniprot/FKBP4_HUMAN FKBP4_HUMAN] Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.<ref>PMID:1279700</ref> <ref>PMID:1376003</ref> <ref>PMID:2378870</ref> <ref>PMID:19945390</ref> <ref>PMID:21730050</ref>
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_15159550}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 15159550 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/1q1c_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_15159550}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-[[1q1c]] is a 1 chain structure of [[FK506 binding protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1C OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q1c ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[FK506 binding protein|FK506 binding protein]]
+*[[FKBP 3D structures|FKBP 3D structures]]
-==Reference==
+*[[Human FKBP52|Human FKBP52]]
-<ref group="xtra">PMID:015159550</ref><ref group="xtra">PMID:010731432</ref><ref group="xtra">PMID:015937899</ref><references group="xtra"/>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Peptidylprolyl isomerase]]
+[[Category: Large Structures]]
-[[Category: Ding, Y.]]
+[[Category: Ding Y]]
-[[Category: Li, P.]]
+[[Category: Li P]]
-[[Category: Lou, Z.]]
+[[Category: Lou Z]]
-[[Category: Rao, Z.]]
+[[Category: Rao Z]]
-[[Category: Shen, B.]]
+[[Category: Shen B]]
-[[Category: Shu, C.]]
+[[Category: Shu C]]
-[[Category: Wu, B.]]
+[[Category: Wu B]]
-[[Category: Isomerase]]
-[[Category: Nuclear protein]]
-[[Category: Phosphorylation]]
-[[Category: Rotamase]]
-[[Category: Tpr repeat]]