1pwl: Difference between revisions

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[[Image:1pwl.png|left|200px]]


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==Crystal structure of human Aldose Reductase complexed with NADP and Minalrestat==
The line below this paragraph, containing "STRUCTURE_1pwl", creates the "Structure Box" on the page.
<StructureSection load='1pwl' size='340' side='right'caption='[[1pwl]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1pwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PWL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFI:2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3-PYRROLIDINE]-1,2,3,5(2H)-TETRONE'>BFI</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
{{STRUCTURE_1pwl| PDB=1pwl |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwl OCA], [https://pdbe.org/1pwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pwl RCSB], [https://www.ebi.ac.uk/pdbsum/1pwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pwl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pw/1pwl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pwl ConSurf].
<div style="clear:both"></div>


===Crystal structure of human Aldose Reductase complexed with NADP and Minalrestat===
==See Also==
 
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
 
__TOC__
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{{ABSTRACT_PUBMED_15146479}}
 
==About this Structure==
1PWL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWL OCA].
 
==Reference==
Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors., El-Kabbani O, Darmanin C, Schneider TR, Hazemann I, Ruiz F, Oka M, Joachimiak A, Schulze-Briese C, Tomizaki T, Mitschler A, Podjarny A, Proteins. 2004 Jun 1;55(4):805-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15146479 15146479]
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Darmanin, C.]]
[[Category: Darmanin C]]
[[Category: El-Kabbani, O.]]
[[Category: El-Kabbani O]]
[[Category: Hazemann, I.]]
[[Category: Hazemann I]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak A]]
[[Category: Mitschler, A.]]
[[Category: Mitschler A]]
[[Category: Oka, M.]]
[[Category: Oka M]]
[[Category: Podjarny, A.]]
[[Category: Podjarny A]]
[[Category: Ruiz, F.]]
[[Category: Ruiz F]]
[[Category: Schneider, T R.]]
[[Category: Schneider TR]]
[[Category: Schulze-Briese, C.]]
[[Category: Schulze-Briese C]]
[[Category: Tomizaki, T.]]
[[Category: Tomizaki T]]
[[Category: Aldose reductase]]
[[Category: Atomic resolution]]
[[Category: Inhibitor binding]]
[[Category: Ternary complex]]
[[Category: X-ray crystallography]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:03:35 2008''

Latest revision as of 16:28, 13 March 2024

Crystal structure of human Aldose Reductase complexed with NADP and MinalrestatCrystal structure of human Aldose Reductase complexed with NADP and Minalrestat

Structural highlights

1pwl is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.1Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ALDR_HUMAN Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1pwl, resolution 1.10Å

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OCA
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