1nu2: Difference between revisions

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-[[Image:1nu2.png|left|200px]]
-{{STRUCTURE_1nu2|  PDB=1nu2  |  SCENE=  }}
+==Crystal structure of the murine Disabled-1 (Dab1) PTB domain-ApoER2 peptide-PI-4,5P2 ternary complex==
+<StructureSection load='1nu2' size='340' side='right'caption='[[1nu2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-===Crystal structure of the murine Disabled-1 (Dab1) PTB domain-ApoER2 peptide-PI-4,5P2 ternary complex===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1nu2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NU2 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_12737822}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nu2 OCA], [https://pdbe.org/1nu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nu2 RCSB], [https://www.ebi.ac.uk/pdbsum/1nu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nu2 ProSAT]</span></td></tr>
-[[1nu2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NU2 OCA].
+</table>
+== Function ==
-==Reference==
+[https://www.uniprot.org/uniprot/DAB1_MOUSE DAB1_MOUSE] Adapter molecule functioning in neural development. May regulate SIAH1 activity.<ref>PMID:9009273</ref>
-<ref group="xtra">PMID:012737822</ref><references group="xtra"/>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nu/1nu2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nu2 ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Blacklow, S C.]]
+[[Category: Blacklow SC]]
-[[Category: Eck, M J.]]
+[[Category: Eck MJ]]
-[[Category: Herz, J.]]
+[[Category: Herz J]]
-[[Category: Jeon, H.]]
+[[Category: Jeon H]]
-[[Category: Song, H K.]]
+[[Category: Song HK]]
-[[Category: Stolt, P C.]]
+[[Category: Stolt PC]]
-[[Category: Beta-sandwich]]
-[[Category: Signaling protein]]