1nnl: Difference between revisions

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[[Image:1nnl.png|left|200px]]


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==Crystal structure of Human Phosphoserine Phosphatase==
The line below this paragraph, containing "STRUCTURE_1nnl", creates the "Structure Box" on the page.
<StructureSection load='1nnl' size='340' side='right'caption='[[1nnl]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1nnl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NNL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
{{STRUCTURE_1nnl| PDB=1nnl |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nnl OCA], [https://pdbe.org/1nnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nnl RCSB], [https://www.ebi.ac.uk/pdbsum/1nnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nnl ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN] Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:[https://omim.org/entry/614023 614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.<ref>PMID:14673469</ref>
== Function ==
[https://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN] Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.<ref>PMID:12777757</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/1nnl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nnl ConSurf].
<div style="clear:both"></div>


===Crystal structure of Human Phosphoserine Phosphatase===
==See Also==
 
*[[Phosphoserine phosphatase|Phosphoserine phosphatase]]
 
== References ==
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<references/>
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{{ABSTRACT_PUBMED_12777757}}
 
==About this Structure==
1NNL is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NNL OCA].
 
==Reference==
<ref group="xtra">PMID:12777757</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphoserine phosphatase]]
[[Category: Large Structures]]
[[Category: Collet, J F.]]
[[Category: Collet JF]]
[[Category: Peeraer, Y.]]
[[Category: De Ranter C]]
[[Category: Rabijns, A.]]
[[Category: Peeraer Y]]
[[Category: Ranter, C De.]]
[[Category: Rabijns A]]
[[Category: Schaftingen, E Van.]]
[[Category: Van Schaftingen E]]
[[Category: Verboven, C.]]
[[Category: Verboven C]]
[[Category: Hpsp]]
[[Category: Phospho-aspartyl]]
[[Category: Phosphoserine phosphatase]]
[[Category: Psp]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:34:52 2009''

Latest revision as of 16:27, 13 March 2024

Crystal structure of Human Phosphoserine PhosphataseCrystal structure of Human Phosphoserine Phosphatase

Structural highlights

1nnl is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.53Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

SERB_HUMAN Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:614023. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.[1]

Function

SERB_HUMAN Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Veiga-da-Cunha M, Collet JF, Prieur B, Jaeken J, Peeraer Y, Rabbijns A, Van Schaftingen E. Mutations responsible for 3-phosphoserine phosphatase deficiency. Eur J Hum Genet. 2004 Feb;12(2):163-6. PMID:14673469 doi:10.1038/sj.ejhg.5201083
  2. ↑ Peeraer Y, Rabijns A, Verboven C, Collet JF, Van Schaftingen E, De Ranter C. High-resolution structure of human phosphoserine phosphatase in open conformation. Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):971-7. Epub 2003, May 23. PMID:12777757

1nnl, resolution 1.53Å

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