1nnl: Difference between revisions

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-{{STRUCTURE_1nnl|  PDB=1nnl  |  SCENE=  }}
-===Crystal structure of Human Phosphoserine Phosphatase===
-{{ABSTRACT_PUBMED_12777757}}
-==Disease==
+==Crystal structure of Human Phosphoserine Phosphatase==
-[[http://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN]] Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:[http://omim.org/entry/614023 614023]]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.<ref>PMID:14673469</ref>
+<StructureSection load='1nnl' size='340' side='right'caption='[[1nnl]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
+== Structural highlights ==
-==Function==
+<table><tr><td colspan='2'>[[1nnl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NNL FirstGlance]. <br>
-[[http://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN]] Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.<ref>PMID:12777757</ref>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nnl OCA], [https://pdbe.org/1nnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nnl RCSB], [https://www.ebi.ac.uk/pdbsum/1nnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nnl ProSAT]</span></td></tr>
-[[1nnl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NNL OCA].
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN] Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:[https://omim.org/entry/614023 614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.<ref>PMID:14673469</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN] Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.<ref>PMID:12777757</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/1nnl_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nnl ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Phosphoserine phosphatase|Phosphoserine phosphatase]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:012777757</ref><references group="xtra"/><references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Phosphoserine phosphatase]]
+[[Category: Large Structures]]
-[[Category: Collet, J F.]]
+[[Category: Collet JF]]
-[[Category: Peeraer, Y.]]
+[[Category: De Ranter C]]
-[[Category: Rabijns, A.]]
+[[Category: Peeraer Y]]
-[[Category: Ranter, C De.]]
+[[Category: Rabijns A]]
-[[Category: Schaftingen, E Van.]]
+[[Category: Van Schaftingen E]]
-[[Category: Verboven, C.]]
+[[Category: Verboven C]]
-[[Category: Hpsp]]
-[[Category: Hydrolase]]
-[[Category: Phospho-aspartyl]]
-[[Category: Phosphoserine phosphatase]]
-[[Category: Psp]]