1n60: Difference between revisions

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[[Image:1n60.png|left|200px]]


{{STRUCTURE_1n60|  PDB=1n60  |  SCENE=  }}
==Crystal Structure of the Cu,Mo-CO Dehydrogenase (CODH); Cyanide-inactivated Form==
 
<StructureSection load='1n60' size='340' side='right'caption='[[1n60]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
===Crystal Structure of the Cu,Mo-CO Dehydrogenase (CODH); Cyanide-inactivated Form===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1n60]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Afipia_carboxidovorans_OM5 Afipia carboxidovorans OM5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N60 FirstGlance]. <br>
{{ABSTRACT_PUBMED_12475995}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.19&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MCN:PTERIN+CYTOSINE+DINUCLEOTIDE'>MCN</scene>, <scene name='pdbligand=OMO:MO(VI)(=O)(OH)2+CLUSTER'>OMO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n60 OCA], [https://pdbe.org/1n60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n60 RCSB], [https://www.ebi.ac.uk/pdbsum/1n60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n60 ProSAT]</span></td></tr>
[[1n60]] is a 6 chain structure of [[Carbon monoxide dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Oligotropha_carboxidovorans Oligotropha carboxidovorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N60 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/DCMS_AFIC5 DCMS_AFIC5] Catalyzes the oxidation of carbon monoxide to carbon dioxide.<ref>PMID:12475995</ref> <ref>PMID:21275368</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n6/1n60_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n60 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Carbon monoxide dehydrogenase|Carbon monoxide dehydrogenase]]
*[[Carbon monoxide dehydrogenase 3D structures|Carbon monoxide dehydrogenase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:012475995</ref><ref group="xtra">PMID:017009862</ref><references group="xtra"/>
__TOC__
[[Category: Oligotropha carboxidovorans]]
</StructureSection>
[[Category: Dobbek, H.]]
[[Category: Afipia carboxidovorans OM5]]
[[Category: Gremer, L.]]
[[Category: Large Structures]]
[[Category: Huber, R.]]
[[Category: Dobbek H]]
[[Category: Kiefersauer, R.]]
[[Category: Gremer L]]
[[Category: Meyer, O.]]
[[Category: Huber R]]
[[Category: Codh]]
[[Category: Kiefersauer R]]
[[Category: Molybdenum]]
[[Category: Meyer O]]
[[Category: Molybdopterin]]
[[Category: Oxidoreductase]]

Latest revision as of 16:27, 13 March 2024

Crystal Structure of the Cu,Mo-CO Dehydrogenase (CODH); Cyanide-inactivated FormCrystal Structure of the Cu,Mo-CO Dehydrogenase (CODH); Cyanide-inactivated Form

Structural highlights

1n60 is a 6 chain structure with sequence from Afipia carboxidovorans OM5. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.19Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DCMS_AFIC5 Catalyzes the oxidation of carbon monoxide to carbon dioxide.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Dobbek H, Gremer L, Kiefersauer R, Huber R, Meyer O. Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15971-6. PMID:12475995 doi:10.1073/pnas.212640899
  2. ↑ Wilcoxen J, Zhang B, Hille R. Reaction of the molybdenum from Oligotropha carboxydovorans with quinones. Biochemistry. 2011 Mar 22;50(11):1910-6. PMID:21275368 doi:10.1021/bi1017182

1n60, resolution 1.19Å

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