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[[Image:1mf1.png|left|200px]]


{{STRUCTURE_1mf1|  PDB=1mf1  |  SCENE=  }}
==Structure of the Recombinant Mouse-Muscle Adenylosuccinate Synthetase Complexed with AMP==
 
<StructureSection load='1mf1' size='340' side='right'caption='[[1mf1]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
===Structure of the Recombinant Mouse-Muscle Adenylosuccinate Synthetase Complexed with AMP===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1mf1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MF1 FirstGlance]. <br>
{{ABSTRACT_PUBMED_12186864}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mf1 OCA], [https://pdbe.org/1mf1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mf1 RCSB], [https://www.ebi.ac.uk/pdbsum/1mf1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mf1 ProSAT]</span></td></tr>
[[1mf1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF1 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PURA1_MOUSE PURA1_MOUSE] Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.<ref>PMID:12482871</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mf/1mf1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mf1 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Adenylosuccinate Synthetase|Adenylosuccinate Synthetase]]
*[[Adenylosuccinate synthetase 3D structures|Adenylosuccinate synthetase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:012186864</ref><references group="xtra"/>
__TOC__
[[Category: Adenylosuccinate synthase]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Borza, T.]]
[[Category: Borza T]]
[[Category: Fromm, H J.]]
[[Category: Fromm HJ]]
[[Category: Honzatko, R B.]]
[[Category: Honzatko RB]]
[[Category: Iancu, C V.]]
[[Category: Iancu CV]]
[[Category: Gtp-binding]]
[[Category: Ligase]]
[[Category: Multigene family]]
[[Category: Purine biosynthesis]]

Latest revision as of 16:26, 13 March 2024

Structure of the Recombinant Mouse-Muscle Adenylosuccinate Synthetase Complexed with AMPStructure of the Recombinant Mouse-Muscle Adenylosuccinate Synthetase Complexed with AMP

Structural highlights

1mf1 is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PURA1_MOUSE Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Borza T, Iancu CV, Pike E, Honzatko RB, Fromm HJ. Variations in the response of mouse isozymes of adenylosuccinate synthetase to inhibitors of physiological relevance. J Biol Chem. 2003 Feb 28;278(9):6673-9. Epub 2002 Dec 12. PMID:12482871 doi:http://dx.doi.org/10.1074/jbc.M210838200

1mf1, resolution 2.70Å

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