1lp4: Difference between revisions

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[[Image:1lp4.png|left|200px]]


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==Crystal structure of a binary complex of the catalytic subunit of protein kinase CK2 with Mg-AMPPNP==
The line below this paragraph, containing "STRUCTURE_1lp4", creates the "Structure Box" on the page.
<StructureSection load='1lp4' size='340' side='right'caption='[[1lp4]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1lp4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LP4 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_1lp4|  PDB=1lp4 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lp4 OCA], [https://pdbe.org/1lp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lp4 RCSB], [https://www.ebi.ac.uk/pdbsum/1lp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lp4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CSK2A_MAIZE CSK2A_MAIZE] Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lp/1lp4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lp4 ConSurf].
<div style="clear:both"></div>


===Crystal structure of a binary complex of the catalytic subunit of protein kinase CK2 with Mg-AMPPNP===
==See Also==
 
*[[Casein kinase 3D structures|Casein kinase 3D structures]]
 
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_15740749}}
 
==About this Structure==
1LP4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LP4 OCA].
 
==Reference==
Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate., Yde CW, Ermakova I, Issinger OG, Niefind K, J Mol Biol. 2005 Mar 25;347(2):399-414. Epub 2005 Jan 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15740749 15740749]
 
Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 A resolution., Niefind K, Guerra B, Pinna LA, Issinger OG, Schomburg D, EMBO J. 1998 May 1;17(9):2451-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9564028 9564028]
 
Expression, purification and crystallization of the catalytic subunit of protein kinase CK2 from Zea mays., Guerra B, Niefind K, Pinna LA, Schomburg D, Issinger OG, Acta Crystallogr D Biol Crystallogr. 1998 Jan 1;54(Pt 1):143-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9761839 9761839]
 
GTP plus water mimic ATP in the active site of protein kinase CK2., Niefind K, Putter M, Guerra B, Issinger OG, Schomburg D, Nat Struct Biol. 1999 Dec;6(12):1100-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10581548 10581548]
 
Crystallization and preliminary characterization of crystals of human protein kinase CK2., Niefind K, Guerra B, Ermakowa I, Issinger OG, Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1680-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11092945 11092945]
 
Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme., Niefind K, Guerra B, Ermakowa I, Issinger OG, EMBO J. 2001 Oct 1;20(19):5320-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11574463 11574463]
 
Expression and characterization of a recombinant maize CK-2 alpha subunit., Boldyreff B, Meggio F, Dobrowolska G, Pinna LA, Issinger OG, Biochim Biophys Acta. 1993 Apr 29;1173(1):32-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8485151 8485151]
 
Cloning and sequencing of the casein kinase 2 alpha subunit from Zea mays., Dobrowolska G, Boldyreff B, Issinger OG, Biochim Biophys Acta. 1991 Dec 2;1129(1):139-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1756176 1756176]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Single protein]]
[[Category: Zea mays]]
[[Category: Zea mays]]
[[Category: Guerra, B.]]
[[Category: Guerra B]]
[[Category: Issinger, O G.]]
[[Category: Issinger O-G]]
[[Category: Niefind, K.]]
[[Category: Niefind K]]
[[Category: Puetter, M.]]
[[Category: Puetter M]]
[[Category: Schomburg, D.]]
[[Category: Schomburg D]]
[[Category: Casein kinase 2]]
[[Category: Ck2]]
[[Category: Dual-cosubstrate specificity]]
[[Category: Protein kinase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:06:39 2008''

Latest revision as of 16:26, 13 March 2024

Crystal structure of a binary complex of the catalytic subunit of protein kinase CK2 with Mg-AMPPNPCrystal structure of a binary complex of the catalytic subunit of protein kinase CK2 with Mg-AMPPNP

Structural highlights

1lp4 is a 1 chain structure with sequence from Zea mays. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.86Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CSK2A_MAIZE Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1lp4, resolution 1.86Å

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