1juv: Difference between revisions

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[[Image:1juv.png|left|200px]]


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==Crystal structure analysis of Dihydrofolate reductase from Bacteriophage T4==
The line below this paragraph, containing "STRUCTURE_1juv", creates the "Structure Box" on the page.
<StructureSection load='1juv' size='340' side='right'caption='[[1juv]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1juv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
{{STRUCTURE_1juv|  PDB=1juv  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1juv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juv OCA], [https://pdbe.org/1juv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1juv RCSB], [https://www.ebi.ac.uk/pdbsum/1juv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1juv ProSAT]</span></td></tr>
 
</table>
===Crystal structure analysis of Dihydrofolate reductase from Bacteriophage T4===
== Function ==
 
[https://www.uniprot.org/uniprot/DYR_BPT4 DYR_BPT4] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
[[1juv]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUV OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/1juv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1juv ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Dihydrofolate reductase]]
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
[[Category: Dihydrofolate reductase]]
__TOC__
[[Category: Enterobacteria phage t4]]
</StructureSection>
[[Category: Moon, J H.]]
[[Category: Escherichia virus T4]]
[[Category: Oh, Y K.]]
[[Category: Large Structures]]
[[Category: Suh, S W.]]
[[Category: Moon JH]]
[[Category: Complexed with nadph]]
[[Category: Oh YK]]
[[Category: Oxidoreductase]]
[[Category: Suh SW]]

Latest revision as of 16:25, 13 March 2024

Crystal structure analysis of Dihydrofolate reductase from Bacteriophage T4Crystal structure analysis of Dihydrofolate reductase from Bacteriophage T4

Structural highlights

1juv is a 1 chain structure with sequence from Escherichia virus T4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DYR_BPT4 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1juv, resolution 1.70Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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