1jqo: Difference between revisions

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OCA

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-[[Image:1jqo.jpg|left|200px]]<br /><applet load="1jqo" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1jqo, resolution 3.00&Aring;" />
-'''Crystal structure of C4-form phosphoenolpyruvate carboxylase from maize'''<br />
-==Overview==
+==Crystal structure of C4-form phosphoenolpyruvate carboxylase from maize==
-Phosphoenolpyruvate carboxylase (PEPC) catalyzes the first step in the, fixation of atmospheric CO(2) during C(4) photosynthesis. The crystal, structure of C(4) form maize PEPC (ZmPEPC), the first structure of the, plant PEPCs, has been determined at 3.0 A resolution. The structure, includes a sulfate ion at the plausible binding site of an allosteric, activator, glucose 6-phosphate. The crystal structure of E. coli PEPC, (EcPEPC) complexed with Mn(2+), phosphoenolpyruvate analog, (3,3-dichloro-2-dihydroxyphosphinoylmethyl-2-propenoate), and an, allosteric inhibitor, aspartate, has also been determined at 2.35 A, resolution. Dynamic movements were found in the ZmPEPC structure, compared, with the EcPEPC structure, around two loops near the active site. On the, basis of these molecular structures, the mechanisms for the carboxylation, reaction and for the allosteric regulation of PEPC are proposed.
+<StructureSection load='1jqo' size='340' side='right'caption='[[1jqo]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1jqo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JQO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqo OCA], [https://pdbe.org/1jqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jqo RCSB], [https://www.ebi.ac.uk/pdbsum/1jqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CAPP1_MAIZE CAPP1_MAIZE] Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/1jqo_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jqo ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-JQO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Zea_mays Zea mays] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoenolpyruvate_carboxylase Phosphoenolpyruvate carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.31 4.1.1.31] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JQO OCA].
+*[[Phosphoenolpyruvate carboxylase|Phosphoenolpyruvate carboxylase]]
+__TOC__
-==Reference==
+</StructureSection>
-Crystal structures of C4 form maize and quaternary complex of E. coli phosphoenolpyruvate carboxylases., Matsumura H, Xie Y, Shirakata S, Inoue T, Yoshinaga T, Ueno Y, Izui K, Kai Y, Structure. 2002 Dec;10(12):1721-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12467579 12467579]
+[[Category: Large Structures]]
-[[Category: Phosphoenolpyruvate carboxylase]]
-[[Category: Single protein]]
 [[Category: Zea mays]]
-[[Category: Kai, Y.]]
+[[Category: Kai Y]]
-[[Category: Matsumura, H.]]
+[[Category: Matsumura H]]
-[[Category: SO4]]
-[[Category: beta barrel]]
-[[Category: carbon dioxide fixation]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:29:25 2007''