Urea transporter: Difference between revisions

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[[Image:3k3f.png|left|200px]]
<StructureSection load='' size='350' side='right' caption='Urea transporter ([[3me1]]' scene='Urea_transporter/3k3fdefault/1' pspeed='8'>


===Crystal Structure of the Urea Transporter from Desulfovibrio Vulgaris===
===Crystal Structure of the Urea Transporter from Desulfovibrio Vulgaris===
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==About this Structure==
==About this Structure==
{{Structure
|PDB= 3me1  |SIZE=400|SCENE= |CAPTION=Urea transporter trimer ([[3me1]]); (<scene name='Urea_transporter/3k3fdefault/1'>initial scene</scene>)
|SITE=
|LIGAND=
|ACTIVITY=
|GENE=
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k3f  FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k3f  OCA], [http://www.ebi.ac.uk/pdbsum/3k3f  PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3k3f  RCSB]</span>
}}


To help give a better idea of how the urea transporter is oriented in the membrane lipid bilayer, <scene name='Urea_transporter/Opm_3k3f/3'>a slab representative of hydrophobic core of the lipid bilayer</scene> as calculated by the [http://opm.phar.umich.edu/protein.php?pdbid=3kg2 Orientations of Proteins in Membranes database](University of Michigan, USA) is shown with the red patch of spheres indicating the boundary of the hydrophobic core closet to the outside of the cell and the dark blue patch of spheres indicating the boundary closest to the inside of the cell.
 
To help give a better idea of how the '''urea transporter''' is oriented in the membrane lipid bilayer, <scene name='Urea_transporter/Opm_3k3f/3'>a slab representative of hydrophobic core of the lipid bilayer</scene> as calculated by the [http://opm.phar.umich.edu/protein.php?pdbid=3kg2 Orientations of Proteins in Membranes database](University of Michigan, USA) is shown with the red patch of spheres indicating the boundary of the hydrophobic core closet to the outside of the cell and the dark blue patch of spheres indicating the boundary closest to the inside of the cell.
[[Image:Opm_periplasmic_topology.gif]] <!--I got this from Eric Martz's [[Mechanosensitive channels: opening and closing]]-->
[[Image:Opm_periplasmic_topology.gif]] <!--I got this from Eric Martz's [[Mechanosensitive channels: opening and closing]]-->


==3D structures of urea transporter==
</StructureSection>
==3D structures of '''urea transporter''' or  '''solute carrier family 14'''==


''Update February 2013''
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


[[8blp]] – hUT 1 + cholesterol derivative – human<br />
[[6qd5]] – hUT 1 (mutant) + cholesterol derivative <br />
[[8blo]] – hUT 2 + choline derivative <br />
[[4ezc]] – bUT + ceramide - bovine<br />
[[4ezd]] – bUT + ceramide + selenourea<br />
[[3k3f]], [[3me1]] – DvUT – ''Desulfovibrio vulgaris''<br />
[[3k3f]], [[3me1]] – DvUT – ''Desulfovibrio vulgaris''<br />
[[3m6e]] – DvUT (mutant)<br />
[[3m6e]] – DvUT (mutant)<br />
[[3k3g]] – DvUT + dimethylurea<br />
[[3k3g]] – DvUT + dimethylurea<br />
[[4ezc]] – bUT + ceramide - bovine<br />
[[7s6e]] – UT + urea ''synechococcus''<br />
[[4ezd]] bUT + ceramide + selenourea<br />


==Reference for the structure==
==Reference for the structure==

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, Jaime Prilusky, David Canner, Michal Harel, Joel L. Sussman