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[[Image:3k3f.png|left|200px]]
<StructureSection load='' size='350' side='right' caption='Urea transporter ([[3me1]]' scene='Urea_transporter/3k3fdefault/1' pspeed='8'>


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{{Structure
|PDB= 3k3f  |SIZE=400|SCENE= |CAPTION= urea transporter ([[3k3f]]), resolution 2.30&Aring; (<scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Default3kg2/1'>initial scene</scene>)
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k3f  FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k3f  OCA], [http://www.ebi.ac.uk/pdbsum/3k3f  PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3k3f  RCSB]</span>
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===Crystal Structure of the Urea Transporter from Desulfovibrio Vulgaris===
===Crystal Structure of the Urea Transporter from Desulfovibrio Vulgaris===


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{{ABSTRACT_PUBMED_19865084}}
{{ABSTRACT_PUBMED_19865084}}


==About this Structure==
==About this Structure==
The structure revealed a monomer of the urea transporter in the asymmetric unit.


However, the urea transporter crystallized as a homotrimer that corresponds to its functional biological state, and this is seen when considering the crystallographic three-fold symmetry axis.


To help give a better idea of how the '''urea transporter''' is oriented in the membrane lipid bilayer, <scene name='Urea_transporter/Opm_3k3f/3'>a slab representative of hydrophobic core of the lipid bilayer</scene> as calculated by the [http://opm.phar.umich.edu/protein.php?pdbid=3kg2 Orientations of Proteins in Membranes database](University of Michigan, USA) is shown with the red patch of spheres indicating the boundary of the hydrophobic core closet to the outside of the cell and the dark blue patch of spheres indicating the boundary closest to the inside of the cell.
[[Image:Opm_periplasmic_topology.gif]] <!--I got this from Eric Martz's [[Mechanosensitive channels: opening and closing]]-->


To help give a better idea of how the urea transporter is oriented in the membrane lipid bilayer,<scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/3kg2opm_mem/10'>a slab representative of hydrophobic core of the lipid bilayer</scene> as calculated by the [http://opm.phar.umich.edu/protein.php?pdbid=3kg2 Orientations of Proteins in Membranes database](University of Michigan, USA) is shown with the red patch of spheres indicating the boundary of the hydrophobic core closet to the outside of the cell and the dark blue patch of spheres indicating the boundary closest to the inside of the cell.
</StructureSection>
[[Image:Opm_periplasmic_topology.gif]] <!--I got this from Eric Martz's [[Mechanosensitive channels: opening and closing]]-->
==3D structures of '''urea transporter''' or  '''solute carrier family 14'''==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


==PDB entry==
[[8blp]] – hUT 1 + cholesterol derivative – human<br />
[[3K3F]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_vulgaris_str._hildenborough Desulfovibrio vulgaris str. hildenborough]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K3F OCA].
[[6qd5]] – hUT 1 (mutant) + cholesterol derivative <br />
[[8blo]] – hUT 2 + choline derivative <br />
[[4ezc]] – bUT + ceramide - bovine<br />
[[4ezd]] – bUT + ceramide + selenourea<br />
[[3k3f]], [[3me1]] – DvUT – ''Desulfovibrio vulgaris''<br />
[[3m6e]] – DvUT (mutant)<br />
[[3k3g]] – DvUT + dimethylurea<br />
[[7s6e]] – UT + urea – ''synechococcus''<br />


==Reference for the structure==
==Reference for the structure==
<ref group="xtra">PMID:19865084</ref><references group="xtra"/>
<ref group="xtra">PMID:19865084</ref><references group="xtra"/>
==See Also==
<ref group="xtra">PMID:20010678</ref><references group="xtra"/>
* For Additional Information, See [[Membrane Channels & Pumps]]


==Reference==
==Reference==
{{Reflist}}<ref group="xtra">PMID:19865084</ref><references group="xtra"/>
{{Reflist}}
[[Category: Desulfovibrio vulgaris str. hildenborough]]
[[Category: Desulfovibrio vulgaris str. hildenborough]]
[[Category: Levin, E J.]]
[[Category: Levin, E J.]]
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''Page started with original page on [[3k3f]] seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:58:46 2010''
''Page started with original page on [[3k3f]] seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:58:46 2010''
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, Jaime Prilusky, David Canner, Michal Harel, Joel L. Sussman
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