Structural Biology: Difference between revisions
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[[Image:373px-X ray diffraction.png|250px|right|thumb| The Steps toward Elucidating the | [[Image:373px-X ray diffraction.png|250px|right|thumb| The Steps toward [[Empirical models|Elucidating the Structures]] of Biological Macromolecules by [[X-ray crystallography]].]] | ||
[[Structural Biology]] is a branch of molecular biology & biochemistry concerned with the the molecular structure of biological macromolecules like proteins and [[Nucleic Acids|nucleic acids]]. It focuses on determining the structure of macromolecules to better understand their function and how to manipulate these macromolecules to develop therapeutics and broaden our understanding of biological phenomena. | [[Structural Biology]] is a branch of molecular biology & biochemistry concerned with the the molecular structure of biological macromolecules like proteins and [[Nucleic Acids|nucleic acids]]. It focuses on determining the structure of macromolecules to better understand their function and how to manipulate these macromolecules to develop therapeutics and broaden our understanding of biological phenomena. | ||
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* [[About Macromolecular Structure | Articles in Proteopedia concerning [[Structural Biology]] include: | ||
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* [[About Macromolecular Structure]] - An Index to pages that explain structural biology terms and concepts. | |||
* Methods of Structure Determination | * Methods of Structure Determination | ||
** [[Empirical models]]: the 3 major methods for determining macromolecular structures. | |||
** NMR | ** NMR | ||
*** [[NMR Ensembles of Models]] | *** [[NMR Ensembles of Models]] | ||
*** [[Quality assessment for molecular models]] | |||
** X-Ray Crystallography | ** X-Ray Crystallography | ||
*** [[Anisotropic refinement]] | |||
*** [[Asymmetric Unit]] | *** [[Asymmetric Unit]] | ||
*** [[Biological Unit]] | *** [[Biological Unit]] | ||
*** [[Electron density maps]] | *** [[Electron density maps]] | ||
*** [[Free R]] | |||
*** [[Quality assessment for molecular models]] | |||
*** [[R value]] | |||
*** [[Resolution]] | |||
*** [[Temperature value]] | |||
*** [[X-ray crystallography]] | *** [[X-ray crystallography]] | ||
* Methods of Structure & Sequence Analysis | * Methods of Structure & Sequence Analysis | ||
** Structural Analysis & Visualization | ** Structural Analysis & Visualization | ||
*** [[Atomic coordinate file]] | |||
*** [[Chime]] | *** [[Chime]] | ||
*** [[CPK]] - Corey-Pauling-Koltun spacefilling molecular models and color scheme for elements | *** [[CPK]] - Corey-Pauling-Koltun spacefilling molecular models and color scheme for elements | ||
*** [[DRuMS]] - set of standard color schemes for macromolecular visualization | *** [[DRuMS]] - set of standard color schemes for macromolecular visualization | ||
*** [[User:Wayne Decatur/Generate Unfolded Structures|Generate Unfolded Structures]] | *** [[User:Wayne Decatur/Generate Unfolded Structures|Generate Unfolded Structures]] | ||
*** [[Improving published models]] | |||
*** [[Molecular modeling and visualization software]] | |||
*** [[Morphs]] | |||
*** [[PDB identification code]] | |||
*** [[Protein Data Bank]] | |||
*** [[Ramachandran Plots]] | |||
*** [[Structural alignment tools]] | |||
*** [[User:Wayne Decatur/Teaching Proteopedia|Teaching Proteopedia]] | *** [[User:Wayne Decatur/Teaching Proteopedia|Teaching Proteopedia]] | ||
*** Homology Model | *** Homology Model | ||
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*** [[User:Wayne Decatur/Sequence analysis tools|Sequence Analysis Tools]] | *** [[User:Wayne Decatur/Sequence analysis tools|Sequence Analysis Tools]] | ||
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To view automatically seeded indices concerning | <br /> | ||
To view automatically seeded indices concerning [[Structural Biology]] See: | |||
*[[: Category:Macromolecule|Macromolecule]] | *[[: Category:Macromolecule|Macromolecule]] | ||
*[[: Category:Nmr|NMR]] | *[[: Category:Nmr|NMR]] | ||
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==See Also== | |||
*[[About Macromolecular Structure]], an index to pages explaining terms and concepts. | |||
*[[Index pages]] | |||