Structural Biology: Difference between revisions

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[[Image:373px-X ray diffraction.png|250px|right|thumb| The Steps toward [[Empirical models|Elucidating the Structures]] of Biological Macromolecules by [[X-ray crystallography]].]]
[[Structural Biology]] is a branch of molecular biology & biochemistry concerned with the the molecular structure of biological macromolecules like proteins and [[Nucleic Acids|nucleic acids]]. It focuses on determining the structure of macromolecules to better understand their function and how to manipulate these macromolecules to develop therapeutics and broaden our understanding of biological phenomena.
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Articles in Proteopedia concerning [[Structural Biology]] include:
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* [[About Macromolecular Structure]] - An Index to pages that explain structural biology terms and concepts.
* Methods of Structure Determination
* Methods of Structure Determination
** [[Empirical models]]: the 3 major methods for determining macromolecular structures.
**  NMR
*** [[NMR Ensembles of Models]]
*** [[Quality assessment for molecular models]]
** X-Ray Crystallography
** X-Ray Crystallography
*** [[X-ray crystallography]]
*** [[Anisotropic refinement]]
*** [[Asymmetric Unit]]
*** [[Asymmetric Unit]]
*** [[Biological Unit]]
*** [[Biological Unit]]
*** [[Electron density maps]]
*** [[Electron density maps]]
** NMR
*** [[Free R]]
*** [[NMR Ensembles of Models]]
*** [[Quality assessment for molecular models]]
 
*** [[R value]]
*** [[Resolution]]
*** [[Temperature value]]
*** [[X-ray crystallography]]
* Methods of Structure & Sequence Analysis
* Methods of Structure & Sequence Analysis
** Structural Analysis & Visualization
** Structural Analysis & Visualization
*** [[Atomic coordinate file]]
*** [[Chime]]
*** [[CPK]] - Corey-Pauling-Koltun spacefilling molecular models and color scheme for elements
*** [[CPK]] - Corey-Pauling-Koltun spacefilling molecular models and color scheme for elements
*** [[Chime]]
*** [[DRuMS]] - set of standard color schemes for macromolecular visualization
*** Jmol
*** [[User:Wayne Decatur/Generate Unfolded Structures|Generate Unfolded Structures]]
**** [[S347/Visualising protein structure|Visualising Protein Structure]] - Introduction to Jmol
*** [[Improving published models]]
**** [[FirstGlance in Jmol]]
*** [[Molecular modeling and visualization software]]
*** [[Morphs]]
*** [[PDB identification code]]
*** [[Protein Data Bank]]
*** [[Ramachandran Plots]]
*** [[Structural alignment tools]]
*** [[User:Wayne Decatur/Teaching Proteopedia|Teaching Proteopedia]]
*** [[User:Wayne Decatur/Teaching Proteopedia|Teaching Proteopedia]]
*** [[User:Wayne Decatur/Generate Unfolded Structures|Generate Unfolded Structures]]
*** Homology Model
*** Homology Model
**** [[User:Wayne Decatur/Homology Modeling|Homology Modeling]]
**** [[User:Wayne Decatur/Homology Modeling|Homology Modeling]]
**** [[User:Emi Nakayama/TRIM5a Homology Models|TRIM5a Homology Models]] - Differences in models as a function of their templates
**** [[User:Emi Nakayama/TRIM5a Homology Models|TRIM5a Homology Models]] - Differences in models as a function of their templates
*** [[DRuMS]] - set of standard color schemes for macromolecular visualization
*** Jmol
**** [[FirstGlance in Jmol]]
**** [[S347/Visualising protein structure|Visualising Protein Structure]] - Introduction to Jmol
** Sequence Analysis
** Sequence Analysis
*** [[User:Wayne Decatur/Sequence analysis tools|Sequence Analysis Tools]]
*** [[User:Wayne Decatur/Sequence analysis tools|Sequence Analysis Tools]]
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To view automatically seeded indices concerning [[Structural Biology]] See:
*[[: Category:Macromolecule|Macromolecule]]
*[[: Category:Nmr|NMR]]
*[[:Category:Structure|Structure]]
*[[: Category:X-ray|X-Ray]]
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==See Also==
*[[About Macromolecular Structure]], an index to pages explaining terms and concepts.
*[[Index pages]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

David Canner, Eric Martz