Structural Biology: Difference between revisions
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[[Image:373px-X ray diffraction.png|250px|right|thumb| The Steps toward [[Empirical models|Elucidating the Structures]] of Biological Macromolecules by [[X-ray crystallography]].]] | |||
[[Structural Biology]] is a branch of molecular biology & biochemistry concerned with the the molecular structure of biological macromolecules like proteins and [[Nucleic Acids|nucleic acids]]. It focuses on determining the structure of macromolecules to better understand their function and how to manipulate these macromolecules to develop therapeutics and broaden our understanding of biological phenomena. | |||
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Articles in Proteopedia concerning [[Structural Biology]] include: | |||
{{#tree:id=SBTopic|openlevels=0| | |||
* [[About Macromolecular Structure]] - An Index to pages that explain structural biology terms and concepts. | |||
* Methods of Structure Determination | * Methods of Structure Determination | ||
** [[Empirical models]]: the 3 major methods for determining macromolecular structures. | |||
** NMR | |||
*** [[NMR Ensembles of Models]] | |||
*** [[Quality assessment for molecular models]] | |||
** X-Ray Crystallography | ** X-Ray Crystallography | ||
*** [[ | *** [[Anisotropic refinement]] | ||
*** [[Asymmetric Unit]] | *** [[Asymmetric Unit]] | ||
*** [[Biological Unit]] | *** [[Biological Unit]] | ||
*** [[Electron density maps]] | *** [[Electron density maps]] | ||
** | *** [[Free R]] | ||
*** [[ | *** [[Quality assessment for molecular models]] | ||
*** [[R value]] | |||
*** [[Resolution]] | |||
*** [[Temperature value]] | |||
*** [[X-ray crystallography]] | |||
* Methods of Structure & Sequence Analysis | * Methods of Structure & Sequence Analysis | ||
** Structural Analysis & Visualization | ** Structural Analysis & Visualization | ||
*** [[Atomic coordinate file]] | |||
*** [[Chime]] | |||
*** [[CPK]] - Corey-Pauling-Koltun spacefilling molecular models and color scheme for elements | *** [[CPK]] - Corey-Pauling-Koltun spacefilling molecular models and color scheme for elements | ||
*** [[ | *** [[DRuMS]] - set of standard color schemes for macromolecular visualization | ||
*** | *** [[User:Wayne Decatur/Generate Unfolded Structures|Generate Unfolded Structures]] | ||
**** [[ | *** [[Improving published models]] | ||
**** [[ | *** [[Molecular modeling and visualization software]] | ||
*** [[Morphs]] | |||
*** [[PDB identification code]] | |||
*** [[Protein Data Bank]] | |||
*** [[Ramachandran Plots]] | |||
*** [[Structural alignment tools]] | |||
*** [[User:Wayne Decatur/Teaching Proteopedia|Teaching Proteopedia]] | *** [[User:Wayne Decatur/Teaching Proteopedia|Teaching Proteopedia]] | ||
*** Homology Model | *** Homology Model | ||
**** [[User:Wayne Decatur/Homology Modeling|Homology Modeling]] | **** [[User:Wayne Decatur/Homology Modeling|Homology Modeling]] | ||
**** [[User:Emi Nakayama/TRIM5a Homology Models|TRIM5a Homology Models]] - Differences in models as a function of their templates | **** [[User:Emi Nakayama/TRIM5a Homology Models|TRIM5a Homology Models]] - Differences in models as a function of their templates | ||
*** [[ | *** Jmol | ||
**** [[FirstGlance in Jmol]] | |||
**** [[S347/Visualising protein structure|Visualising Protein Structure]] - Introduction to Jmol | |||
** Sequence Analysis | ** Sequence Analysis | ||
*** [[User:Wayne Decatur/Sequence analysis tools|Sequence Analysis Tools]] | *** [[User:Wayne Decatur/Sequence analysis tools|Sequence Analysis Tools]] | ||
}} | }} | ||
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To view automatically seeded indices concerning [[Structural Biology]] See: | |||
*[[: Category:Macromolecule|Macromolecule]] | |||
*[[: Category:Nmr|NMR]] | |||
*[[:Category:Structure|Structure]] | |||
*[[: Category:X-ray|X-Ray]] | |||
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==See Also== | |||
*[[About Macromolecular Structure]], an index to pages explaining terms and concepts. | |||
*[[Index pages]] |