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==Cryo-EM structure of human cGMP-bound open CNGA1 channel in Na+/Ca2+== | ==Cryo-EM structure of human cGMP-bound open CNGA1 channel in Na+/Ca2+== | ||
<StructureSection load='7lfx' size='340' side='right'caption='[[7lfx]]' scene=''> | <StructureSection load='7lfx' size='340' side='right'caption='[[7lfx]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LFX FirstGlance]. <br> | <table><tr><td colspan='2'>[[7lfx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LFX FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lfx OCA], [https://pdbe.org/7lfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lfx RCSB], [https://www.ebi.ac.uk/pdbsum/7lfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lfx ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PCG:CYCLIC+GUANOSINE+MONOPHOSPHATE'>PCG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lfx OCA], [https://pdbe.org/7lfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lfx RCSB], [https://www.ebi.ac.uk/pdbsum/7lfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lfx ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/CNGA1_HUMAN CNGA1_HUMAN] Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CNGA1_HUMAN CNGA1_HUMAN] Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.[UniProtKB:Q00194] | |||
==See Also== | |||
*[[Ion channels 3D structures|Ion channels 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Han Y]] | [[Category: Han Y]] | ||
[[Category: Jiang Y]] | [[Category: Jiang Y]] | ||
[[Category: Xue J]] | [[Category: Xue J]] | ||
Latest revision as of 17:59, 6 March 2024
Cryo-EM structure of human cGMP-bound open CNGA1 channel in Na+/Ca2+Cryo-EM structure of human cGMP-bound open CNGA1 channel in Na+/Ca2+
Structural highlights
DiseaseCNGA1_HUMAN Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry. FunctionCNGA1_HUMAN Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.[UniProtKB:Q00194] See Also |
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