7l29: Difference between revisions
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==Crystal structure of the catalytic domain of human PDE3A bound to AMP== | ==Crystal structure of the catalytic domain of human PDE3A bound to AMP== | ||
<StructureSection load='7l29' size='340' side='right'caption='[[7l29]]' scene=''> | <StructureSection load='7l29' size='340' side='right'caption='[[7l29]], [[Resolution|resolution]] 2.08Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L29 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7l29]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L29 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l29 OCA], [https://pdbe.org/7l29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l29 RCSB], [https://www.ebi.ac.uk/pdbsum/7l29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l29 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l29 OCA], [https://pdbe.org/7l29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l29 RCSB], [https://www.ebi.ac.uk/pdbsum/7l29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l29 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/PDE3A_HUMAN PDE3A_HUMAN] Brachydactyly-arterial hypertension syndrome. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PDE3A_HUMAN PDE3A_HUMAN] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.[UniProtKB:Q9Z0X4] | |||
==See Also== | |||
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Garvie C]] | [[Category: Garvie C]] | ||
[[Category: Horner SW]] | [[Category: Horner SW]] | ||