7k0q: Difference between revisions
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==== | ==Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, myriocin-bound== | ||
<StructureSection load='7k0q' size='340' side='right'caption='[[7k0q]]' scene=''> | <StructureSection load='7k0q' size='340' side='right'caption='[[7k0q]], [[Resolution|resolution]] 3.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7k0q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K0Q FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k0q OCA], [https://pdbe.org/7k0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k0q RCSB], [https://www.ebi.ac.uk/pdbsum/7k0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k0q ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=VRP:Myriocin'>VRP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k0q OCA], [https://pdbe.org/7k0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k0q RCSB], [https://www.ebi.ac.uk/pdbsum/7k0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k0q ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/SPTC1_HUMAN SPTC1_HUMAN] Hereditary sensory and autonomic neuropathy type 1;Juvenile amyotrophic lateral sclerosis. The disease is caused by variants affecting the gene represented in this entry. SPTLC1 variants at Ser-331 are responsible for severe hereditary motor and sensory neuropathy (HMSN) forms, whose core features are severe, diffuse muscle wasting and hypotonia, motor and sensory disturbances, foot ulcers, amputations and/or burns, joint hypermobility, cataracts and considerable growth retardation.<ref>PMID:23454272</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SPTC1_HUMAN SPTC1_HUMAN] Serine palmitoyltransferase (SPT) (PubMed:19416851). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core (PubMed:19416851). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19416851). Required for adipocyte cell viability and metabolic homeostasis (By similarity).[UniProtKB:O35704]<ref>PMID:19416851</ref> | |||
==See Also== | |||
*[[Serine palmitoyltransferase 3D structures|Serine palmitoyltransferase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Z | [[Category: Kalathur R]] | ||
[[Category: Lee CH]] | |||
[[Category: Myasnikov A]] | |||
[[Category: Niu Y]] | |||
[[Category: Wang Y]] | |||
[[Category: Zhang Z]] | |||
[[Category: Zhao H]] | |||